Pathogenesis of COVID‐19 described through the lens of an undersulfated and degraded epithelial and endothelial glycocalyx
HN du Preez, C Aldous, MR Hayden… - The FASEB …, 2022 - Wiley Online Library
The glycocalyx surrounds every eukaryotic cell and is a complex mesh of proteins and
carbohydrates. It consists of proteoglycans with glycosaminoglycan side chains, which are …
carbohydrates. It consists of proteoglycans with glycosaminoglycan side chains, which are …
COVID-19: Targeting proteases in viral invasion and host immune response
S Seth, J Batra, S Srinivasan - Frontiers in Molecular Biosciences, 2020 - frontiersin.org
An acute respiratory disorder (COVID-19) that accelerated across the globe has been found
to be caused by a novel strain of coronaviruses (SARS-CoV-2). The absence of a specific …
to be caused by a novel strain of coronaviruses (SARS-CoV-2). The absence of a specific …
Withania somnifera (L.) Dunal (Ashwagandha) for the possible therapeutics and clinical management of SARS-CoV-2 infection: Plant-based drug discovery and …
M Singh, K Jayant, D Singh, S Bhutani… - Frontiers in Cellular …, 2022 - frontiersin.org
Coronavirus disease 2019 (COVID-19) pandemic has killed huge populations throughout
the world and acts as a high-risk factor for elderly and young immune-suppressed patients …
the world and acts as a high-risk factor for elderly and young immune-suppressed patients …
Peramivir: a novel intravenous neuraminidase inhibitor for treatment of acute influenza infections
Peramivir is a novel cyclopentane neuraminidase inhibitor of influenza virus. It was
approved by the Food and Drug Administration in December 2014 for treatment of acute …
approved by the Food and Drug Administration in December 2014 for treatment of acute …
Protective role of kallistatin in vascular and organ injury
J Chao, G Bledsoe, L Chao - Hypertension, 2016 - Am Heart Assoc
534 Hypertension September 2016 vasodilation is unrelated to the tissue kallikrein–kinin
system. 18 In addition, kallistatin transgenic mice were found to have significantly lower …
system. 18 In addition, kallistatin transgenic mice were found to have significantly lower …
The host protease KLK5 primes and activates spike proteins to promote human betacoronavirus replication and lung inflammation
Coronaviruses rely on host proteases to activate the viral spike protein, which facilitates
fusion with the host cell membrane and the release of viral genomic RNAs into the host cell …
fusion with the host cell membrane and the release of viral genomic RNAs into the host cell …
Transcriptome profiling and protease inhibition experiments identify proteases that activate H3N2 influenza A and influenza B viruses in murine airways
A Harbig, M Mernberger, L Bittel, S Pleschka… - Journal of Biological …, 2020 - ASBMB
Cleavage of influenza virus hemagglutinin (HA) by host proteases is essential for virus
infectivity. HA of most influenza A and B (IAV/IBV) viruses is cleaved at a monobasic motif by …
infectivity. HA of most influenza A and B (IAV/IBV) viruses is cleaved at a monobasic motif by …
Kallikreins emerge as new regulators of viral infections
Kallikrein-related peptidases (KLKs) or kallikreins have been linked to diverse (patho)
physiological processes, such as the epidermal desquamation and inflammation, seminal …
physiological processes, such as the epidermal desquamation and inflammation, seminal …
Integrated analysis of miRNA-mRNA expression of newly emerging swine H3N2 influenza virus cross-species infection with tree shrews
Q Wang, Z Liu, X Zeng, Y Zheng, L Lan, X Wang, Z Lai… - Virology Journal, 2024 - Springer
Background Cross-species transmission of zoonotic IAVs to humans is potentially
widespread and lethal, posing a great threat to human health, and their cross-species …
widespread and lethal, posing a great threat to human health, and their cross-species …
[HTML][HTML] Kallistatin: double-edged role in angiogenesis, apoptosis and oxidative stress
J Chao, P Li, L Chao - Biological chemistry, 2017 - degruyter.com
Kallistatin, via its two structural elements–an active site and a heparin-binding domain–
displays a double-edged function in angiogenesis, apoptosis and oxidative stress. First …
displays a double-edged function in angiogenesis, apoptosis and oxidative stress. First …