Oxidative stress has been implicated in both normal aging and in various
neurodegenerative disorders and may be a common mechanism underlying various forms …

INTRODUCTION Phosphorylation of structural and regulatory proteins is a major
intracellular control mechanism in eukaryotes. The phosphoryl-ation state of a protein is a …

THE tau gene encodes a protein (Tau) that is a major neuronal microtubule-associated
protein localized mostly in axons1–4. It has microtubule-binding and tubulin-polymerizing …

Abstract LONG-TERM potentiation (LTP) is a synaptic mechanism thought to be involved in
learning and memory1. Long-term depression (LTD), an activity-dependent decrease in …

The immunosuppressive agents cyclosporin A (CsA) and FK 506 bind to distinct families of
intracellular proteins (immunophilins) termed cyclophilins and FK 506-binding proteins …

The effectiveness of long-term potentiation (LTP) as a mechanism for information storage
would be severely limited if processes that decrease synaptic strength did not also exist. In …

Specificity of protein kinases and phosphatases may be achieved through
compartmentalization with preferred substrates. In neurons, adenosine 3′, 5 …

The mitochondrial localization of the membrane proteins Bcl-2 and Bcl-xL is essential for
their anti-apoptotic function. Here we show that mitochondrial FK506-binding protein 38 …

The microbial products cyclosporin A (CsA), FK506 and rapamycin are potent
immunosuppressive agents. The introduction of CsA in the early 1970's significantly …

In hippocampal neurons, the scaffold protein AKAP79 recruits the phosphatase calcineurin
to L-type Ca2+ channels and couples Ca2+ influx to activation of calcineurin and of its …