ALDH2 in alcoholic heart diseases: molecular mechanism and clinical implications
Alcoholic cardiomyopathy is manifested as cardiac hypertrophy, disrupted contractile
function and myofibrillary architecture. An ample amount of clinical and experimental …
function and myofibrillary architecture. An ample amount of clinical and experimental …
[HTML][HTML] Impact of alcohol on glycemic control and insulin action
JL Steiner, KT Crowell, CH Lang - Biomolecules, 2015 - mdpi.com
Alcohol has profound effects on tissue and whole-body fuel metabolism which contribute to
the increased morbidity and mortality in individuals with alcohol use disorder. This review …
the increased morbidity and mortality in individuals with alcohol use disorder. This review …
[HTML][HTML] Adiponectin knockout accentuates high fat diet-induced obesity and cardiac dysfunction: role of autophagy
Adiponectin (APN), an adipose-derived adipokine, offers cardioprotective effects although
the precise mechanism of action remains unclear. This study was designed to examine the …
the precise mechanism of action remains unclear. This study was designed to examine the …
[HTML][HTML] Mitochondrial ALDH2 protects against lipopolysaccharide-induced myocardial contractile dysfunction by suppression of ER stress and autophagy
J Pang, H Peng, S Wang, X Xu, F Xu, Q Wang… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Lipopolysaccharide (LPS), an essential component of outer membrane of the Gram-negative
bacteria, plays a pivotal role in myocardial anomalies in sepsis. Recent evidence depicted …
bacteria, plays a pivotal role in myocardial anomalies in sepsis. Recent evidence depicted …
[HTML][HTML] A novel protective mechanism for mitochondrial aldehyde dehydrogenase (ALDH2) in type i diabetes-induced cardiac dysfunction: role of AMPK-regulated …
Y Guo, W Yu, D Sun, J Wang, C Li, R Zhang… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Mitochondrial aldehyde dehydrogenase (ALDH2) is known to offer myocardial protection
against stress conditions including ischemia-reperfusion injury, alcoholism and diabetes …
against stress conditions including ischemia-reperfusion injury, alcoholism and diabetes …
Total saponins from Panax japonicus attenuate acute alcoholic liver oxidative stress and hepatosteatosis by p62-related Nrf2 pathway and AMPK-ACC/PPARα axis in …
Ethnopharmacological relevance Panax japonicus (T. Nees) CA Mey.(PJ) has been used as
a tonic traditional Chinese medicine (TCM) for years. Based on its meridian tropism in liver …
a tonic traditional Chinese medicine (TCM) for years. Based on its meridian tropism in liver …
[PDF][PDF] RETRACTED: Aldehyde dedydrogenase-2 plays a beneficial role in ameliorating chronic alcohol-induced hepatic steatosis and inflammation through …
Methods: Wild type Friend virus B (FVB) and ALDH2 transgenic mice were placed on a 4%
alcohol or control diet for 12 weeks. Serum levels of aspartate aminotransferase (AST) …
alcohol or control diet for 12 weeks. Serum levels of aspartate aminotransferase (AST) …
AMP-dependent kinase and autophagic flux are involved in aldehyde dehydrogenase-2-induced protection against cardiac toxicity of ethanol
Mitochondrial aldehyde dehydrogenase-2 (ALDH2) alleviates ethanol toxicity although the
precise mechanism is unclear. This study was designed to evaluate the effect of ALDH2 on …
precise mechanism is unclear. This study was designed to evaluate the effect of ALDH2 on …
mTOR‐STAT3‐notch signalling contributes to ALDH2‐induced protection against cardiac contractile dysfunction and autophagy under alcoholism
W Ge, J Ren - Journal of cellular and molecular medicine, 2012 - Wiley Online Library
Abstract Mitochondrial aldehyde dehydrogenase‐2 (ALDH2) has been shown to benefit
myopathic changes following alcohol intake, although the precise mechanism is still unclear …
myopathic changes following alcohol intake, although the precise mechanism is still unclear …
[HTML][HTML] Embelin averts MPTP-induced dysfunction in mitochondrial bioenergetics and biogenesis via activation of SIRT1
SP Rao, N Sharma, SV Kalivendi - Biochimica et Biophysica Acta (BBA) …, 2020 - Elsevier
Parkinson's disease (PD) is a chronic neurodegenerative disease characterized by the
death of dopamine neurons of Substantia nigra pars compacta (SNpc) leading to motor …
death of dopamine neurons of Substantia nigra pars compacta (SNpc) leading to motor …