BDNF signaling in context: From synaptic regulation to psychiatric disorders
Brain-derived neurotrophic factor (BDNF) is a neuropeptide that plays numerous important
roles in synaptic development and plasticity. While its importance in fundamental physiology …
roles in synaptic development and plasticity. While its importance in fundamental physiology …
Neurotrophic factor BDNF, physiological functions and therapeutic potential in depression, neurodegeneration and brain cancer
Brain-derived neurotrophic factor (BDNF) is one of the most distributed and extensively
studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin …
studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin …
The physiology of regulated BDNF release
T Brigadski, V Leßmann - Cell and Tissue Research, 2020 - Springer
The neurotrophic factor BDNF is an important regulator for the development of brain circuits,
for synaptic and neuronal network plasticity, as well as for neuroregeneration and …
for synaptic and neuronal network plasticity, as well as for neuroregeneration and …
Molecular mechanisms of early and late LTP
LTP is the most intensively studied cellular model of the memory and generally divided at
least two distinct phases as early and late. E-LTP requires activation of CaMKII that initiates …
least two distinct phases as early and late. E-LTP requires activation of CaMKII that initiates …
Targeting homeostatic synaptic plasticity for treatment of mood disorders
ET Kavalali, LM Monteggia - Neuron, 2020 - cell.com
Ketamine exerts rapid antidepressant action in depressed and treatment-resistant
depressed patients within hours. At the same time, ketamine elicits a unique form of …
depressed patients within hours. At the same time, ketamine elicits a unique form of …
[HTML][HTML] Pleiotropic effects of BDNF on the cerebellum and hippocampus: Implications for neurodevelopmental disorders
Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the
mammalian brain, essential not only to the development of the central nervous system but …
mammalian brain, essential not only to the development of the central nervous system but …
Ketamine and rapid antidepressant action: new treatments and novel synaptic signaling mechanisms
Ketamine is an open channel blocker of ionotropic glutamatergic N-Methyl-D-Aspartate
(NMDA) receptors. The discovery of its rapid antidepressant effects in patients with …
(NMDA) receptors. The discovery of its rapid antidepressant effects in patients with …
Mechanisms that modulate and diversify BDNF functions: implications for hippocampal synaptic plasticity
AP De Vincenti, AS Ríos, G Paratcha… - Frontiers in cellular …, 2019 - frontiersin.org
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that has pleiotropic effects on
neuronal morphology and synaptic plasticity that underlie hippocampal circuit development …
neuronal morphology and synaptic plasticity that underlie hippocampal circuit development …
The role of neurotrophin signaling in age-related cognitive decline and cognitive diseases
T Numakawa, H Odaka - International Journal of Molecular Sciences, 2022 - mdpi.com
Neurotrophins are a family of secreted proteins expressed in the peripheral nervous system
and the central nervous system that support neuronal survival, synaptic plasticity, and …
and the central nervous system that support neuronal survival, synaptic plasticity, and …
A synaptic locus for TrkB signaling underlying ketamine rapid antidepressant action
Ketamine produces rapid antidepressant action in patients with major depression or
treatment-resistant depression. Studies have identified brain-derived neurotrophic factor …
treatment-resistant depression. Studies have identified brain-derived neurotrophic factor …