Abstract Introduction The protein Klotho (KL) was first discovered in KL-deficient mice, which
developed a syndrome similar to premature aging in humans. Since then, KL has been …

Multiple sclerosis (MS) is a multifactorial disease of the central nervous system (CNS)
characterized by an inflammatory process and demyelination. The etiology of the disease is …

The extracellular domain of transmembrane alpha-Klotho (αKlotho, hereinafter simply called
Klotho) is cleaved by secretases and released into the circulation as soluble Klotho. Soluble …

The vertebrate endoskeleton is not a mere frame for muscle attachment to facilitate
locomotion, but is a massive organ integrated with many physiologic functions including …

Background Klotho has both anticancer and hormone‐like functions. But the research on
Klotho and cancer is mainly based on animal experiments and small‐scale clinical research …

In this chapter, we will describe what has been learned about Klotho and its potential
functions in the brain. Klotho is localized in the choroid plexus and, to a lesser extent, in …

Recurrent seizures in epilepsy may lead to progressive neuronal damage, which can
diminish health-related quality of life. Evaluation and control of pathological processes in the …

Abstract α-Klotho is well described as an anti-aging protein, with critical roles in kidney
function as a transmembrane co-receptor for FGF23, and as a soluble factor in serum. α …

The Klotho protein is a recently discovered protein and its overexpression is associated with
life extension. Klotho deficiency or silencing of the Klotho gene in mice leads to an …

Brain expression of klotho was first described with the initial discovery of the klotho gene.
The prominent age-regulating effects of klotho are attributed to regulation of ion homeostasis …