Pulmonary hypertension

A Mocumbi, M Humbert, A Saxena, ZC Jing… - Nature Reviews …, 2024 - nature.com
Pulmonary hypertension encompasses a range of conditions directly or indirectly leading to
elevated pressures within the pulmonary arteries. Five main groups of pulmonary …

Evaluation and management of right-sided heart failure: a scientific statement from the American Heart Association

MA Konstam, MS Kiernan, D Bernstein, B Bozkurt… - Circulation, 2018 - Am Heart Assoc
Background and Purpose: The diverse causes of right-sided heart failure (RHF) include,
among others, primary cardiomyopathies with right ventricular (RV) involvement, RV …

Macrophage–NLRP3 activation promotes right ventricle failure in pulmonary arterial hypertension

R Al-Qazazi, PDA Lima, SZ Prisco, F Potus… - American journal of …, 2022 - atsjournals.org
Rationale: Pulmonary arterial hypertension (PAH) often results in death from right ventricular
failure (RVF). NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin …

Downregulation of microRNA-126 contributes to the failing right ventricle in pulmonary arterial hypertension

F Potus, G Ruffenach, A Dahou, C Thebault… - Circulation, 2015 - Am Heart Assoc
Background—Right ventricular (RV) failure is the most important factor of both morbidity and
mortality in pulmonary arterial hypertension (PAH). However, the underlying mechanisms …

World Health Organization Group I pulmonary hypertension: epidemiology and pathophysiology

KW Prins, T Thenappan - Cardiology clinics, 2016 - cardiology.theclinics.com
Pulmonary hypertension (PH) is defined as mean pulmonary arterial pressure(PAP)
measured by right heart catheterization of 25 mm Hg or higher at rest. 1 The most recent …

Guidelines and recommendations for targeted neonatal echocardiography and cardiac point-of-care ultrasound in the neonatal intensive care unit: an update from the …

PJ McNamara, A Jain, A El-Khuffash… - Journal of the American …, 2024 - Elsevier
Targeted neonatal echocardiography (TNE) involves the use of comprehensive
echocardiography to appraise cardiovascular physiology and neonatal hemodynamics to …

Metabolomic signatures associated with pulmonary arterial hypertension outcomes

H Pi, L Xia, DD Ralph, SG Rayner, A Shojaie… - Circulation …, 2023 - Am Heart Assoc
Background: Pulmonary arterial hypertension (PAH) is a complex disease characterized by
progressive right ventricular (RV) failure leading to significant morbidity and mortality …

Dominant role for regulatory T cells in protecting females against pulmonary hypertension

R Tamosiuniene, O Manouvakhova… - Circulation …, 2018 - Am Heart Assoc
Rationale: Pulmonary arterial hypertension (PH) is a life-threatening condition associated
with immune dysregulation and abnormal regulatory T cell (Treg) activity, but it is currently …

Right heart failure in pulmonary hypertension

SJ Cassady, GV Ramani - Cardiology clinics, 2020 - cardiology.theclinics.com
Pulmonary hypertension (PH), previously defined as a mean pulmonary artery pressure of
greater than 25 mm Hg, has recently been redefined by the Sixth World Symposium on …

Transcriptional profiling unveils molecular subgroups of adaptive and maladaptive right ventricular remodeling in pulmonary hypertension

F Khassafi, P Chelladurai, C Valasarajan… - Nature cardiovascular …, 2023 - nature.com
Right ventricular (RV) function is critical to prognosis in all forms of pulmonary hypertension.
Here we perform molecular phenotyping of RV remodeling by transcriptome analysis of RV …