Research in developmental biology has been recently enriched by a multitude of in vitro
models recapitulating key milestones of mammalian embryogenesis. These models obviate …

Detailed studies of the embryo allow an increasingly mechanistic understanding of
development, which has proved of profound relevance to human disease. The last decade …

The development of mouse embryos can be partially recapitulated by combining embryonic
stem cells (ESCs), trophoblast stem cells (TS), and extra-embryonic endoderm (XEN) stem …

Generating cells with the molecular and functional properties of embryo cells and with full
developmental potential is an aim with fundamental biological significance. Here we report …

Successful specification of the two mouse blastocyst inner cell mass (ICM) lineages (the
primitive endoderm (PrE) and epiblast) is a prerequisite for continued development and …

Stem-cell derived in vitro systems, such as organoids or embryoids, hold great potential for
modeling in vivo development. Full control over their initial composition, scalability, and …

Implantation of the human embryo commences a critical developmental stage that
comprises profound morphogenetic alteration of embryonic and extra-embryonic tissues …

Embryogenesis is supported by dynamic loops of cellular interactions. Here, we create a
partial mouse embryo model to elucidate the principles of epiblast (Epi) and extra-embryonic …

During mammalian development and homeostasis, cells often transition from a multilineage
primed state to one of several differentiated cell types that are marked by the expression of …

The pluripotent epiblast gives rise to all tissues and organs in the adult body. Its
differentiation starts at gastrulation, when the epiblast generates mesoderm and endoderm …