Isolation and characterization of extracellular vesicles and future directions in diagnosis and therapy

KP De Sousa, I Rossi, M Abdullahi… - Wiley …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) are a unique and heterogeneous class of lipid bilayer
nanoparticles secreted by most cells. EVs are regarded as important mediators of …

The emerging role of exosomes in mental disorders

S Saeedi, S Israel, C Nagy, G Turecki - Translational psychiatry, 2019 - nature.com
Exosomes are a class of extracellular vesicles of endocytic origin, which are released by
cells and are accessible in biofluids, such as saliva, urine, and plasma. These vesicles are …

Alzheimer's disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

M Sardar Sinha, A Ansell-Schultz, L Civitelli… - Acta …, 2018 - Springer
The gradual deterioration of cognitive functions in Alzheimer's disease is paralleled by a
hierarchical progression of amyloid-beta and tau brain pathology. Recent findings indicate …

Extracellular vesicle quantification and characterization: common methods and emerging approaches

TA Hartjes, S Mytnyk, GW Jenster, V van Steijn… - Bioengineering, 2019 - mdpi.com
Extracellular vesicles (EVs) are a family of small membrane vesicles that carry information
about cells by which they are secreted. Growing interest in the role of EVs in intercellular …

Overview of extracellular vesicles, their origin, composition, purpose, and methods for exosome isolation and analysis

LM Doyle, MZ Wang - Cells, 2019 - mdpi.com
The use of extracellular vesicles, specifically exosomes, as carriers of biomarkers in
extracellular spaces has been well demonstrated. Despite their promising potential, the use …

Exosomes in cancer diagnostics

YH Soung, S Ford, V Zhang, J Chung - Cancers, 2017 - mdpi.com
Exosomes are endosome derived extracellular vesicles of 30–120 nm size ranges.
Exosomes have been identified as mediators of cell-to-cell communication by transferring …

Elucidating methods for isolation and quantification of exosomes: a review

TK Kurian, S Banik, D Gopal, S Chakrabarti… - Molecular …, 2021 - Springer
Exosomes are the smallest extracellular vesicles present in most of the biological fluids.
They are found to play an important role in cell signaling, immune response, tumor …

Extracellular vesicles as signaling mediators and disease biomarkers across biological barriers

P Simeone, G Bologna, P Lanuti… - International journal of …, 2020 - mdpi.com
Extracellular vesicles act as shuttle vectors or signal transducers that can deliver specific
biological information and have progressively emerged as key regulators of organized …

Exosomes/microvesicles from induced pluripotent stem cells deliver cardioprotective miRNAs and prevent cardiomyocyte apoptosis in the ischemic myocardium

Y Wang, L Zhang, Y Li, L Chen, X Wang, W Guo… - International journal of …, 2015 - Elsevier
Background/objectives Induced pluripotent stem cells (iPS) exhibit enhanced survival and
proliferation in ischemic tissues. However, the therapeutic application of iPS cells is limited …

The mini player with diverse functions: extracellular vesicles in cell biology, disease, and therapeutics

A Thakur, X Ke, YW Chen, P Motallebnejad… - Protein & …, 2022 - academic.oup.com
Extracellular vesicles (EVs) are tiny biological nanovesicles ranging from approximately 30–
1000 nm in diameter that are released into the extracellular matrix of most cell types and in …