Piflufolastat F 18: diagnostic first approval

SJ Keam - Molecular Diagnosis & Therapy, 2021 - Springer
Abstract Piflufolastat F 18 (PYLARIFY®) is an 18 F-labelled diagnostic imaging agent that
has been developed by Progenics Pharmaceuticals Inc., a Lantheus company, for positron …

Synthetic approaches to the new drugs approved during 2021

EL McInturff, SP France, CA Leverett… - Journal of Medicinal …, 2023 - ACS Publications
Each year, new drugs are introduced to the market, representing structures that have affinity
for biological targets implicated in human diseases and conditions. These new chemical …

Bone metastases are measurable: the role of whole-body MRI and positron emission tomography

DE Oprea-Lager, MCF Cysouw, R Boellaard… - Frontiers in …, 2021 - frontiersin.org
Metastatic tumor deposits in bone marrow elicit differential bone responses that vary with the
type of malignancy. This results in either sclerotic, lytic, or mixed bone lesions, which can …

Detection of prostate cancer with 18F-DCFPyL PET/CT compared to final histopathology of radical prostatectomy specimens: is PSMA-targeted biopsy feasible? The …

YJL Bodar, BHE Jansen, JP Van Der Voorn… - World journal of …, 2021 - Springer
Purpose In primary prostate cancer (PCa) patients, accurate staging and histologic grading
are crucial to guide treatment decisions. 18 F-DCFPyL (PSMA)-PET/CT has been …

Using prostate‐specific membrane antigen positron‐emission tomography to guide prostate biopsies and stage men at high‐risk of prostate cancer

YJL Bodar, LMS Boevé, PJ van Leeuwen… - BJU …, 2023 - Wiley Online Library
Objective To assess whether a diagnostic pathway in which prostate‐specific membrane
antigen (PSMA) positron‐emission tomography (PET)/computed tomography (CT) is used as …

Enzymatic synthesis of fluorinated compounds

X Cheng, L Ma - Applied Microbiology and Biotechnology, 2021 - Springer
Fluorinated compounds are widely used in the fields of molecular imaging, pharmaceuticals,
and materials. Fluorinated natural products in nature are rare, and the introduction of …

Validation of simplified uptake measures against dynamic Patlak Ki for quantification of lesional 89Zr-Immuno-PET antibody uptake

JE Wijngaarden, MC Huisman, YWS Jauw… - European journal of …, 2023 - Springer
Purpose Positron emission tomography imaging of zirconium-89-labelled monoclonal
antibodies (89Zr-Immuno-PET) allows for visualisation and quantification of antibody uptake …

Prospective Evaluation of 18F-DCFPyL PET/CT in Detection of High-Risk Localized Prostate Cancer: Comparison With mpMRI

S Gaur, E Mena, SA Harmon… - American Journal of …, 2020 - Am Roentgen Ray Soc
OBJECTIVE. The purpose of this study was to assess the utility of PET with (2 S)-2-[[(1 S)-1-
carboxy-5-[(6-(18F) fluoranylpyridine-3-carbonyl) amino] pentyl] carbamoylamino] …

Repeatability of quantitative 18F-DCFPyL PET/CT measurements in metastatic prostate cancer

BHE Jansen, MCF Cysouw, AN Vis… - Journal of Nuclear …, 2020 - Soc Nuclear Med
Quantitative evaluation of radiolabeled prostate-specific membrane antigen (PSMA) PET
scans may be used to monitor treatment response in patients with prostate cancer (PCa). To …

Prostate-specific membrane antigen targeted pet/CT imaging in patients with colon, gastric and pancreatic cancer

FA Vuijk, F Kleiburg, WA Noortman, L Heijmen… - Cancers, 2022 - mdpi.com
Simple Summary Prostate-specific membrane antigen (PSMA)-targeted PET/CT imaging is
increasingly being used for (re) staging in prostate cancer. Although PSMA suggests …