The kruppel-like factor (KLF) family, diseases, and physiological events

K Yuce, AI Ozkan - Gene, 2023 - Elsevier
Abstract The Kruppel-Like Factor family of regulatory proteins, which has 18 members, is
transcription factors. This family contains zinc finger proteins, regulates the activation and …

Krüppel-like factor-9 and Krüppel-like factor-13: highly related, multi-functional, transcriptional repressors and activators of oncogenesis

FA Simmen, I Alhallak, RCM Simmen - Cancers, 2023 - mdpi.com
Simple Summary Krüppel-like Factor-9 (KLF9) and Krüppel-like Factor-13 (KLF13) are
highly related proteins that function as inducers and/or repressors of specific target gene …

Accurate allocation of multimapped reads enables regulatory element analysis at repeats

A Morrissey, J Shi, DQ James, S Mahony - Genome research, 2024 - genome.cshlp.org
Transposable elements (TEs) and other repetitive regions have been shown to contain gene
regulatory elements, including transcription factor binding sites. However, regulatory …

SF3B4 promotes Twist1 expression and clear cell renal cell carcinoma progression by facilitating the export of KLF 16 mRNA from the nucleus to the cytoplasm

Z Yang, YX Wang, JK Wen, HT Gao, ZW Han… - Cell Death & …, 2023 - nature.com
Splicing factor 3B subunit 4 (SF3B4) plays important functional roles not only in pre-mRNA
splicing, but also in the regulation of transcription, translation, and cell signaling, and its …

Kruppel like factor 16 promotes lung adenocarcinoma progression by upregulating lamin B2

X Jiao, W Gao, H Ren, Y Wu, T Li, S Li, H Yan - Bioengineered, 2022 - Taylor & Francis
Lung cancer is one of the most common causes of cancer-related death. In the past decade,
the treatment and diagnosis of lung cancer have progressed significantly in early efforts to …

Lysine methyltransferase SMYD2 enhances androgen receptor signaling to modulate CRPC cell resistance to enzalutamide

J Li, Z Hong, J Zhang, S Zheng, F Wan, Z Liu, B Dai - Oncogene, 2024 - nature.com
Androgen receptors (ARs) play key roles in prostate cancer (PCa) progression and
castration-resistant prostate cancer (CRPC) resistance to drug therapy. SET and MYND …

Krüppel-like factors in tumors: Key regulators and therapeutic avenues

Y Zhang, C Yao, Z Ju, D Jiao, D Hu, L Qi, S Liu… - Frontiers in …, 2023 - frontiersin.org
Krüppel-like factors (KLFs) are a group of DNA-binding transcriptional regulators with
multiple essential functions in various cellular processes, including proliferation, migration …

KLF16 downregulates the expression of tumor suppressor gene TGFBR3 to promote bladder cancer proliferation and migration

X Chen, P Wang, T Ou, J Li - Cancer Management and Research, 2022 - Taylor & Francis
Introduction Krüppel-like factors (KLFs), which comprise 17 family members, exert important
functions during the development of cancer. The role of KLF16 seems controversial in …

[HTML][HTML] Transcription factor KLF16 activates MAGT1 to regulate the tumorigenesis and progression of breast cancer

L Li, X Zhang, Y Li, B Xiao, S Pei… - International …, 2022 - spandidos-publications.com
Breast cancer is the most frequent cause of cancer‑related mortality among women
worldwide. The present study aimed to explore the role of magnesium transporter protein 1 …

[HTML][HTML] STIL facilitates the development and malignant progression of triple-negative breast cancer through activation of Fanconi anemia pathway via interacting with …

M Wang, B Pan, Y Hu, J Gao, L Hou, Z Yu, M Li… - Translational …, 2024 - Elsevier
Background STIL is an important cell cycle-regulating protein specifically recruited to the
mitotic centrosome to promote the replication of centrioles in dividing cells. However, the …