Could polygenic risk scores be useful in psychiatry?: a review
Importance Polygenic risk scores (PRS) are predictors of the genetic susceptibility to
diseases, calculated for individuals as weighted counts of thousands of risk variants in which …
diseases, calculated for individuals as weighted counts of thousands of risk variants in which …
Pleiotropy and cross-disorder genetics among psychiatric disorders
Genome-wide analyses of common and rare genetic variations have documented the
heritability of major psychiatric disorders, established their highly polygenic genetic …
heritability of major psychiatric disorders, established their highly polygenic genetic …
Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups
Attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are
highly heritable neurodevelopmental conditions, with considerable overlap in their genetic …
highly heritable neurodevelopmental conditions, with considerable overlap in their genetic …
Shared genetic risk factors and causal association between psoriasis and coronary artery disease
Psoriasis and coronary artery disease (CAD) are related comorbidities that are well
established, but whether a genetic basis underlies this is not well studied. We apply trans …
established, but whether a genetic basis underlies this is not well studied. We apply trans …
Investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseases
An epidemiological association between multiple sclerosis (MS) and inflammatory bowel
disease (IBD) is well established, but whether this reflects a shared genetic aetiology, and …
disease (IBD) is well established, but whether this reflects a shared genetic aetiology, and …
Genetic estimates of correlation and causality between blood-based biomarkers and psychiatric disorders
There is a long-standing interest in exploring the relationship between blood-based
biomarkers and psychiatric disorders, despite their causal role being difficult to resolve in …
biomarkers and psychiatric disorders, despite their causal role being difficult to resolve in …
Phenomenology, epidemiology and aetiology of postpartum psychosis: a review
Postpartum psychoses are a severe form of postnatal mood disorders, affecting 1–2 in every
1000 deliveries. These episodes typically present as acute mania or depression with …
1000 deliveries. These episodes typically present as acute mania or depression with …
The contribution of copy number variants to psychiatric symptoms and cognitive ability
Copy number variants (CNVs) are deletions and duplications of DNA sequence. The most
frequently studied CNVs, which are described in this review, are recurrent CNVs that occur …
frequently studied CNVs, which are described in this review, are recurrent CNVs that occur …
Identifying loci with different allele frequencies among cases of eight psychiatric disorders using CC-GWAS
WJ Peyrot, AL Price - Nature genetics, 2021 - nature.com
Psychiatric disorders are highly genetically correlated, but little research has been
conducted on the genetic differences between disorders. We developed a new method …
conducted on the genetic differences between disorders. We developed a new method …
Toward generalizable and transdiagnostic tools for psychosis prediction: an independent validation and improvement of the NAPLS-2 risk calculator in the multisite …
Background Transition to psychosis is among the most adverse outcomes of clinical high-
risk (CHR) syndromes encompassing ultra-high risk (UHR) and basic symptom states …
risk (CHR) syndromes encompassing ultra-high risk (UHR) and basic symptom states …