Signaling pathways and potential therapeutic targets in acute respiratory distress syndrome (ARDS)

Q Huang, Y Le, S Li, Y Bian - Respiratory Research, 2024 - Springer
Acute respiratory distress syndrome (ARDS) is a common condition associated with critically
ill patients, characterized by bilateral chest radiographical opacities with refractory …

From genes to systems: the role of food supplementation in the regulation of sepsis-induced inflammation

Y Prado, D Aravena, S Gatica, FM Llancalahuen… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Systemic inflammation includes a widespread immune response to a harmful stimulus that
results in extensive systemic damage. One common example of systemic inflammation is …

Vitamin D supplementation during intensive care unit stay is associated with improved outcomes in critically ill patients with sepsis: a cohort study

B Yang, Y Zhu, X Zheng, T Li, K Niu, Z Wang, X Lu… - Nutrients, 2023 - mdpi.com
Background: Vitamin D, as a common micronutrient, has been widely used in critically ill
patients. However, whether supplementation of vitamin D in adult patients with sepsis can …

Fibroblast Upregulation of Vitamin D Receptor Represents a Self-Protective Response to Limit Fibroblast Proliferation and Activation during Pulmonary Fibrosis

J Wei, J Zhan, H Ji, Y Xu, Q Xu, X Zhu, Y Liu - Antioxidants, 2023 - mdpi.com
Dysregulation of vitamin D receptor (VDR) is implicated in chronic obstructive pulmonary
disease. However, whether VDR dysregulation contributes to the development of pulmonary …

MicroRNA-451 from Human Umbilical Cord-Derived Mesenchymal Stem Cell Exosomes Inhibits Alveolar Macrophage Autophagy via Tuberous Sclerosis Complex 1 …

Z Jia, L Li, P Zhao, G Fei, S Li, Q Song, G Liu… - Biomedical and …, 2024 - Elsevier
Objective Our previous studies established that microRNA (miR)-451 from human umbilical
cord mesenchymal stem cell-derived exosomes (hUC-MSC-Exos) alleviates acute lung …

Regulation of Pro-Inflammatory Macrophage Polarization via Lipid Nanoparticles Mediated Delivery of Anti-Prostaglandin-E2 siRNA

A Almatroudi, MA Alsahli, MA Syed, AA Khan… - Current Issues in …, 2022 - mdpi.com
Pro-inflammatory macrophage polarization is crucial in acute inflammatory diseases like
Acute lung injury (ALI), and acute respiratory distress syndrome (ARDS). Prostaglandin E2 …

[PDF][PDF] The epigenetic effects of glucocorticoids, sex hormones and vitamin D as steroidal hormones in rheumatic musculoskeletal diseases

E Gotelli, R Campitiello, E Hysa… - Clinical and …, 2024 - clinexprheumatol.org
Chronic rheumatological diseases are multifactorial conditions in which both the
neuroendocrine hormone pathway, including cortisol, sex hormones and active vitamin D3 …

Vitexin mitigates oxidative stress, mitochondrial damage, pyroptosis and regulates small nucleolar RNA host gene 1/DNA methyltransferase 1/microRNA-495 axis in …

A Zaki, M Mohsin, S Khan, A Khan, S Ahmad… - …, 2024 - Springer
Materials and methods We developed an acute lung injury model using C57BL/6 mice and
MLE-12 cells. Through a combination of network pharmacology and in vitro screening …

Vitamin D may assist the UPR against sodium fluoride-induced damage by reducing RIPK1, ATG5, BECN1, oxidative stress and increasing caspase-3 in the …

V Yüksek, S Dede, S Çetin, A Usta… - Journal of Trace Elements …, 2023 - Elsevier
Background Out of all measure systemic exposure to fluorides can cause defect of skeletal
and dental fluorosis. Endoplasmic reticulum (ER) stress is caused by fluorine-induced …

Boric Acid Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice

X Zhang, G Wang, S Chen - Biological Trace Element Research, 2024 - Springer
Acute lung injury (ALI) poses a significant medical challenge due to its widespread
occurrence and high mortality rates. Despite extensive efforts, current clinical interventions …