Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

Diseases of muscle that are caused by pathological interactions between muscle and the
immune system are devastating, but rare. However, muscle injuries that involve trauma and …

Proper muscle function constitutes a precondition for good heath and an active lifestyle
during an individual's lifespan and any deviations from normal skeletal muscle development …

Recently, a new regulatory circuitry has been identified in which RNAs can crosstalk with
each other by competing for shared microRNAs. Such competing endogenous RNAs …

Notch signaling has been shown over the past few decades to play fundamental roles in a
plethora of developmental processes in an evolutionarily conserved fashion. Notch …

Notch signaling is a conserved cell fate regulator during development and postnatal tissue
regeneration. Using skeletal muscle satellite cells as a model and through myogenic cell …

Notch is an ancient transmembrane receptor with crucial roles in cell-fate choices. Although
the 'canonical'Notch pathway and its core members are well established–involving ligand …

Transforming growth factor-β (TGF-β) is a potent inhibitor of skeletal muscle differentiation,
but the molecular mechanism and signaling events that lead to this inhibition are poorly …

Although skeletal muscles appear superficially alike at different anatomical locations, in
reality there is considerably more diversity than previously anticipated. Heterogeneity is not …

Notch receptors and their cognate ligands transduce crucial signals between cells in various
tissues, and have been conserved across millions of years of evolution. Mutations in Notch …