IL-6 is usually described as a pleiotropic cytokine produced in response to tissue injury or
infection. As a pro-inflammatory cytokine, IL-6 activates innate and adaptative immune …

Obesity is a condition associated with an increased risk of metabolic disorders, and in
particular of type-2 diabetes (T2D). The treatment and prevention of obesity and associated …

Menopause-related decline in estrogen levels is accompanied by a change in adipose
tissue distribution from a gynoid to an android and an increased prevalence of obesity in …

Arterial stiffness is often increased in overweight/obese subjects before the development of
hypertension. It is also one of the earliest indicators of increased cardiovascular disease risk …

Interleukin (IL)-6 is a pleotropic cytokine with various physiological and pathophysiological
functions in different cells and tissues. In cells residing within white adipose tissue, several …

One of the concepts explaining the coincidence of obesity and type 2 diabetes (T2D) is the
metaflammation theory. This chronic, low-grade inflammatory state originating from …

Adipose tissue (AT) is a highly heterogeneous organ. Beside the heterogeneity associated
to different tissue types (white, brown, and 'brite') and its location-related heterogeneity …

Metabolic syndrome (MetS) and osteoporosis are two medical problems plaguing the
ageing populations worldwide. Though seemingly distinctive to each other, metabolic …

Adipokines are active molecules with pleiotropic effects produced by adipose tissue and
involved in obesity-related metabolic and cardiovascular diseases. Arterial stiffness, which is …

A sedentary lifestyle is associated with overweight/obesity, which involves excessive fat
body accumulation, triggering structural and functional changes in tissues, organs, and body …