Protein homeostasis (proteostasis) requires the timely degradation of misfolded proteins and
their aggregates by protein quality control (PQC), of which molecular chaperones are an …

Highly sophisticated mechanisms that modulate protein structure and function, which involve
synthesis and degradation, have evolved to maintain cellular homeostasis. Perturbations in …

The extensive links between proteotoxic stress, protein aggregation and pathologies
ranging from ageing to neurodegeneration underscore the importance of understanding …

Genetic and environmental factors responsible for numerous neurodegenerative diseases
vary between disorders, yet age remains a universal risk factor. Age-associated decline in …

Autophagy is a process traditionally known to contribute to cellular cleaning through the
removal of intracellular components in lysosomes. In recent years, intensive scrutiny at the …

Proteotoxicity and Cardiac Dysfunction — Alzheimer's Disease of the Heart? | New England
Journal of Medicine Skip to main content The New England Journal of Medicine homepage …

Cells maintain a healthy proteome through continuous evaluation of the quality of each of
their proteins. Quality control requires the coordinated action of chaperones and proteolytic …

Proteasomes are multienzyme complexes that maintain protein homeostasis (proteostasis)
and important cellular functions through the degradation of misfolded, redundant, and …

Proteotoxic stresses and aging cause breakdown of cellular protein homeostasis, allowing
misfolded proteins to form aggregates, which dedicated molecular machines have evolved …

Protein misfolding causes aggregation and build-up in a variety of brain diseases. There are
numeral molecules that are linked with the protein homeostasis mechanism. Molecular …