Coordination of DNA single strand break repair
R Abbotts, DM Wilson III - Free Radical Biology and Medicine, 2017 - Elsevier
The genetic material of all organisms is susceptible to modification. In some instances, these
changes are programmed, such as the formation of DNA double strand breaks during …
changes are programmed, such as the formation of DNA double strand breaks during …
Poly (ADP-ribose) polymerases in double-strand break repair: focus on PARP1, PARP2 and PARP3
Abstract Poly (ADP-ribosyl) ation (PARylation) is a post-translational modification of proteins
catalysed by Poly (ADP-ribose) polymerases (PARP). A wealth of recent advances in the …
catalysed by Poly (ADP-ribose) polymerases (PARP). A wealth of recent advances in the …
Bimetallic Organic Frameworks of High Piezovoltage for Sono‐Piezo Dynamic Therapy
Q Wang, Y Tian, M Yao, J Fu, L Wang… - Advanced …, 2023 - Wiley Online Library
Piezoelectric materials produce charges to directly act on cancer medium or promote the
generation of reactive oxygen species (ROS) for novel tumor therapy triggered by …
generation of reactive oxygen species (ROS) for novel tumor therapy triggered by …
FMRP promotes transcription-coupled homologous recombination via facilitating TET1-mediated m5C RNA modification demethylation
RNA modifications regulate a variety of cellular processes including DNA repair. The RNA
methyltransferase TRDMT1 generates methyl-5-cytosine (m5C) on messenger RNA (mRNA) …
methyltransferase TRDMT1 generates methyl-5-cytosine (m5C) on messenger RNA (mRNA) …
ARID1A deficiency impairs the DNA damage checkpoint and sensitizes cells to PARP inhibitors
Abstract ARID1A, SWI/SNF chromatin remodeling complex subunit, is a recently identified
tumor suppressor that is mutated in a broad spectrum of human cancers. Thus, it is of …
tumor suppressor that is mutated in a broad spectrum of human cancers. Thus, it is of …
The RNA m5C modification in R-loops as an off switch of Alt-NHEJ
The roles of R-loops and RNA modifications in homologous recombination (HR) and other
DNA double-stranded break (DSB) repair pathways remain poorly understood. Here, we find …
DNA double-stranded break (DSB) repair pathways remain poorly understood. Here, we find …
m5C modification of mRNA serves a DNA damage code to promote homologous recombination
Recruitment of DNA repair proteins to DNA damage sites is a critical step for DNA repair.
Post-translational modifications of proteins at DNA damage sites serve as DNA damage …
Post-translational modifications of proteins at DNA damage sites serve as DNA damage …
The involvement of nucleotide excision repair proteins in the removal of oxidative DNA damage
N Kumar, S Raja, B Van Houten - Nucleic acids research, 2020 - academic.oup.com
The six major mammalian DNA repair pathways were discovered as independent
processes, each dedicated to remove specific types of lesions, but the past two decades …
processes, each dedicated to remove specific types of lesions, but the past two decades …
The current state of eukaryotic DNA base damage and repair
DNA damage is a natural hazard of life. The most common DNA lesions are base, sugar,
and single-strand break damage resulting from oxidation, alkylation, deamination, and …
and single-strand break damage resulting from oxidation, alkylation, deamination, and …
DNA damage during the G0/G1 phase triggers RNA-templated, Cockayne syndrome B-dependent homologous recombination
L Wei, S Nakajima, S Böhm… - Proceedings of the …, 2015 - National Acad Sciences
Damage repair mechanisms at transcriptionally active sites during the G0/G1 phase are
largely unknown. To elucidate these mechanisms, we introduced genome site-specific …
largely unknown. To elucidate these mechanisms, we introduced genome site-specific …