The tryptophan catabolite (TRYCAT) pathway is implicated in the pathophysiology of
schizophrenia (SCZ) since the rate-limiting enzyme indoleamine-dioxygenase (IDO) may be …

Background There is now evidence that affective disorders including major depressive
disorder (MDD) and bipolar disorder (BD) are mediated by immune-inflammatory and nitro …

Nowadays, the role of trace elements (TE) is of growing interest because dyshomeostasis of
selenium (Se), manganese (Mn), zinc (Zn), and copper (Cu) is supposed to be a risk factor …

Metabolite profiling is an indispensable part of drug discovery and development, enabling a
comprehensive understanding of the drug's metabolic behavior. Liquid chromatography …

Deriving from targeted kinase inhibitors (TKIs), targeted covalent kinase inhibitors (TCKIs)
are a new class of TKIs that are covalently bound to their target residue of kinase receptors …

Non-small cell lung cancer (NSCLC) is a significant subtype of lung cancer, and poses a
dangerous global threat. One of the current approaches of NSCLC treatment is a …

Preclinical studies in animals often require frequent blood sampling over prolonged periods.
A preferred method in rats is the implantation of a polyurethane catheter into the jugular …

Volumetric absorption microsampling devices offer minimally invasive and user-friendly
collection of capillary blood in volumes as low as 10 μl. Herein we describe the assay …

Baloxavir marboxil (BXM) is a cap-dependent nucleic acid endonuclease inhibitor, which
exerts its antiviral effects after being metabolized to its active form baloxavir acid (BXA) …

Toxicological analysis requires broad screening for both therapeutically prescribed and illicit
compounds, including their metabolites. This research sought to develop reliable, fast and …