Over the past decade, the gut microbiota has received considerable attention for its
interactions with the host. Microbial β-glucuronidase generated by this community has …

The diversity of oligo-and polysaccharides provides an abundance of biological roles for
these carbohydrates. The enzymes hydrolysing these compounds, the glycoside hydrolases …

The aim of this study was to obtain data about the epidemiology of the different types of
mucopolysaccharidoses in Japan and Switzerland and to compare with similar data from …

The dose-limiting side effect of the common colon cancer chemotherapeutic CPT-11 is
severe diarrhea caused by symbiotic bacterial β-glucuronidases that reactivate the drug in …

The selective inhibition of bacterial β-glucuronidases was recently shown to alleviate drug-
induced gastrointestinal toxicity in mice, including the damage caused by the widely used …

The intestinal milieu is astonishingly complex and home to a constantly changing mixture of
small and large molecules, along with an abundance of bacteria, viral particles, and …

Heparan sulfate proteoglycans (HSPGs) mediate essential interactions throughout the
extracellular matrix (ECM), providing signals that regulate cellular growth and development …

Abstract Not “from above”, but “from the side”: Configuration‐retaining β‐glycosidases
protonate their substrate either anti or syn to the endocyclic C1− O bond as the first step in …

The emergence of disease and dearth of effective pharmacological agents on most
therapeutic fronts, constitutes a major threat to global public health and man's existence …

Background: Hyaluronic acid (HA) is the most abundant glycosaminoglycan of vertebrate
extracellular spaces and is specifically degraded by a β-1, 4 glycosidase. Bee venom …