Alzheimer's Disease (AD) is a neurodegenerative brain disorder in which many biological
dysfunctions are involved. Among them, two main types of lesions were discovered and …

It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

Alzheimer disease is characterized by abnormal protein deposits in the brain, such as
extracellular amyloid plaques and intracellular neurofibrillary tangles. The tangles are made …

Microtubule-associated Tau proteins belong to a family of factors that polymerize tubulin
dimers and stabilize microtubules. Tau is strongly expressed in neurons, localized in the …

Accelerated multi‐dimensional NMR spectroscopy is a prerequisite for high‐throughput
applications, studying short‐lived molecular systems and monitoring chemical reactions in …

Tau is the major microtubule-associated protein in neuronal axons. It aggregates into"
neurofibrillary tangles" during the course of Alzheimer disease. Binding to microtubules and …

Post-translationally modified proteins make up the majority of the proteome and establish, to
a large part, the impressive level of functional diversity in higher, multi-cellular organisms …

Tau, a natively unstructured protein that regulates the organization of neuronal microtubules,
is also found in high concentrations in neurofibrillary tangles of Alzheimer's disease and …

Although the biological significance of protein phosphorylation in cellular signaling is widely
appreciated, methods to directly detect these post-translational modifications in situ are …

The neuronal Tau protein is involved in stabilizing microtubules but is also the major
component of the paired helical filaments (PHFs), the intracellular aggregates that …