The contributions of cooperative groups to performing large-cohort clinical trials and long-
term survivorship studies have facilitated advances in treatment, supportive care and …

As good health is a lifetime issue, long-term follow up is an important part of evaluating any
medical condition or treatment. This is well appreciated in epidemiologic studies where …

Background Survivors of childhood cancer develop early and severe chronic health
conditions (CHCs). A quantitative landscape of morbidity of survivors, however, has not …

However, in the early years of these studies, many were limited by dependence upon self-
reported outcomes or registry data, smaller population sizes and restriction to single disease …

Abstract The World Health Organization recently launched the Global Initiative for Childhood
Cancer aiming to substantially increase survival among children with cancer by 2030. The …

Long-term complications such as radiation-induced second malignancies occur in a subset
of patients following radiation-therapy, particularly relevant in pediatric patients due to the …

Background Children, teenagers and young adults who survived cancer are prone to
developing late effects. The burden of late effects across a large number of conditions, in …

The last decades have seen increased concern about the possible effects of low to
moderate doses of ionizing radiation (IR) exposure on cognitive function. An interdisciplinary …

Background Treatment options for childhood cancer have improved substantially, although
in many low-and middle-income countries survival is lagging behind. Integral childhood …

Background Childhood cancer survivorship issues represent an established public health
challenge. Most late adverse effects (LAEs) have been demonstrated to be time and …