Five vascular endothelial growth factor receptor (VEGFR) ligands (VEGF-A,-B,–C,-D, and
placental growth factor [PlGF]) constitute the VEGF family. VEGF-A binds VEGF receptors 1 …

Estrogen receptors (ERs) are localized to many sites within the cell, potentially contributing
to overall estrogen action. In the nucleus, estrogen mainly modulates gene transcription, and …

Over the past decade, clinical and basic research has demonstrated that estrogen has a
dramatic impact on the response to vascular injury and the development of atherosclerosis …

Stroke disrupts the homeostatic balance within the brain and is associated with a significant
accumulation of necrotic cellular debris, fluid, and peripheral immune cells in the central …

Within the last few years, there has been a growing interest in the neuroprotective effects of
estrogen and the possible beneficial effects of estrogen in neurodegenerative diseases such …

Epidemiological studies correlate moderate red wine consumption to reduced incidence of
cardiovascular disease. Resveratrol is a polyphenolic compound in red wine that has …

Rho kinase (ROCK) proteins are Rho-GTPase activated serine/threonine kinases that
function as modulators of actin-myosin cytoskeletal dynamics via regulation of Lin11, Isl-1 & …

Rapid uterine vasodilatation after estrogen administration is believed to be mediated by
endothelial production of nitric oxide (NO) via endothelial NO synthase (eNOS). However …

The benefits of dietary antioxidants against cardiovascular disease have been examined in
numerous clinical trials and animal models, yet there is limited evidence linking …

Flavonoids, such as daidzein and genistein, present in dietary plants like soybean, have
unique chemical properties with biological activity relevant to cancer. Many flavonoids and …