Mechanoaccumulative elements of the mammalian actin cytoskeleton

ES Schiffhauer, T Luo, K Mohan, V Srivastava, X Qian… - Current Biology, 2016 - cell.com
To change shape, divide, form junctions, and migrate, cells reorganize their cytoskeletons in
response to changing mechanical environments [1–4]. Actin cytoskeletal elements, including …

Mechanochemical signaling directs cell-shape change

ES Schiffhauer, DN Robinson - Biophysical journal, 2017 - cell.com
For specialized cell function, as well as active cell behaviors such as division, migration, and
tissue development, cells must undergo dynamic changes in shape. To complete these …

Fascin limits Myosin activity within Drosophila border cells to control substrate stiffness and promote migration

MC Lamb, CP Kaluarachchi, TI Lansakara… - Elife, 2021 - elifesciences.org
A key regulator of collective cell migrations, which drive development and cancer
metastasis, is substrate stiffness. Increased substrate stiffness promotes migration and is …

How the mechanobiome drives cell behavior, viewed through the lens of control theory

P Kothari, C Johnson, C Sandone… - Journal of cell …, 2019 - journals.biologists.com
Cells have evolved sophisticated systems that integrate internal and external inputs to
coordinate cell shape changes during processes, such as development, cell identity …

Dynamic myosin activation promotes collective morphology and migration by locally balancing oppositional forces from surrounding tissue

G Aranjuez, A Burtscher, K Sawant… - Molecular biology of …, 2016 - Am Soc Cell Biol
Migrating cells need to overcome physical constraints from the local microenvironment to
navigate their way through tissues. Cells that move collectively have the additional …

Meta-analysis of the Boyle van 't Hoff relation: Turgor and leak models explain non-ideal volume equilibrium

DJ Olver, JD Benson - Cryobiology, 2023 - Elsevier
There has been much recent attention paid to the interaction of cell volume, its regulation,
and the molecular biology of the cell. Cells are generally assumed to behave as linear …

Mechanical phenotyping of K562 cells by the Micropipette Aspiration Technique allows identifying mechanical changes induced by drugs

A Di Cerbo, V Rubino, F Morelli, G Ruggiero, R Landi… - Scientific reports, 2018 - nature.com
Mechanical properties of living cells can be used as reliable markers of their state, such as
the presence of a pathological state or their differentiation phase. The mechanical behavior …

Specific prostaglandins are produced in the migratory cells and the surrounding substrate to promote Drosophila border cell migration

SQ Mellentine, HN Brown, AS Ramsey, J Li… - Frontiers in cell and …, 2024 - frontiersin.org
Introduction: A key regulator of collective cell migration is prostaglandin (PG) signaling.
However, it remains largely unclear whether PGs act within the migratory cells or their …

Myosin IIB assembly state determines its mechanosensitive dynamics

ES Schiffhauer, Y Ren, VA Iglesias, P Kothari… - Journal of Cell …, 2019 - rupress.org
Dynamical cell shape changes require a highly sensitive cellular system that can respond to
chemical and mechanical inputs. Myosin IIs are key players in the cell's ability to react to …

Chemical characterization of non‐psychoactive Cannabis sativa L. extracts, in vitro antiproliferative activity and induction of apoptosis in chronic myelogenous …

L Anceschi, A Codeluppi, V Brighenti… - Phytotherapy …, 2022 - Wiley Online Library
In this study, extracts from non‐psychoactive Cannabis sativa L. varieties were characterized
by means of ultra high‐performance liquid chromatography coupled with high‐resolution …