Heart failure (HF) is considered as a severe health problem worldwide, while cardiac fibrosis
is one of the main driving factors for the progress of HF. Cardiac fibrosis was characterized …

A great deal of experimental evidence suggests that ligands can stabilize different receptor
active states that go on to interact with cellular signaling proteins to form a range of different …

Summary Growth differentiation factor 15 (GDF15) induces weight loss and increases insulin
action in obese rodents. Whether and how GDF15 improves insulin action without weight …

The bone marrow contains peripheral nerves that promote haematopoietic regeneration
after irradiation or chemotherapy (myeloablation), but little is known about how this is …

Beta‐blockers are widely used medications for a variety of indications, including heart
failure, myocardial infarction, cardiac arrhythmias, and hypertension. Genetic variability in …

Carvedilol is among the most effective β-blockers for improving survival after myocardial
infarction. Yet the mechanisms by which carvedilol achieves this superior clinical profile are …

Immunotherapy based on immunecheckpoint blockade (ICB) using antibodies induces
rejection of tumours and brings clinical benefit in patients with various cancer types …

Bone remodelling, the mechanism by which vertebrates regulate bone mass, comprises two
phases, namely resorption by osteoclasts and formation by osteoblasts; osteoblasts are …

Excessive caloric intake is thought to be sensed by the brain, which then activates
thermogenesis as a means of preventing obesity. The sympathetic nervous system, through …

Numerous genetic loci have been associated with systolic blood pressure (SBP) and
diastolic blood pressure (DBP) in Europeans 1, 2, 3. We now report genome-wide …