Background Iron content is increased in the substantia nigra of persons with Parkinson's
disease and may contribute to the pathophysiology of the disorder. Early research suggests …

Background Randomized pre-post designs, with outcomes measured at baseline and after
treatment, have been commonly used to compare the clinical effectiveness of two competing …

Importance Lower back pain (LBP) is a prevalent and challenging condition in primary care.
The effectiveness of an individually tailored self-management support tool delivered via a …

Importance The opioid crisis creates challenges for cancer pain management. Acupuncture
confers clinical benefits for chronic nonmalignant pain, but its effectiveness in cancer …

Importance Cytisinicline (cytisine) is a plant-based alkaloid that, like varenicline, binds
selectively to α4β2 nicotinic acetylcholine receptors, which mediate nicotine dependence …

Many texts are excellent sources of knowledge about individual statistical tools, but the art of
data analysis is about choosing and using multiple tools. Instead of presenting isolated …

Noted for its comprehensive coverage, this greatly expanded new edition now covers the
use of univariate and multivariate effect sizes. Many measures and estimators are reviewed …

Background Intention-to-treat (ITT) analysis requires all randomised individuals to be
included in the analysis in the groups to which they were randomised. However, there is …

Background Tirzepatide is a novel dual glucose-dependent insulinotropic polypeptide (GIP)
and GLP-1 receptor agonist under development for the treatment of type 2 diabetes. In this …

Objective To determine the effect on weight of two mobile technology‐based (mHealth)
behavioral weight loss interventions in young adults. Methods Randomized, controlled …