Small-molecule kinase inhibitors are being continuously explored as new anticancer
therapeutics. Kinases are the phosphorylating enzymes which regulate numerous cellular …

The epidermal growth factor receptor (EGFR) plays a critical role in the tumorigenesis of
various forms of cancer. Targeting the mutant forms of EGFR has been identified as an …

Almost 80% of lung cancer diagnoses each year correspond to non-small cell lung cancer
(NSCLC). The percentage of NSCLC with EGFR overexpression ranges from 40% to 89 …

Epidermal growth factor receptor (EGFR) is a vital intermediate in cell signaling pathway
including cell proliferation, angiogenesis, apoptosis, and metastatic spread and also having …

Cancer is one of the leading causes of death. Globally a huge number of deaths and new
incidences are reported annually. Heterocyclic compounds have been proved to be very …

Quinazoline and its derivatives have drawn much attention in the development of potential
antitumor agents. Here, we synthesized a series of 1, 2, 3-triazole derivatives of quinazoline …

Cancer diseases remain major health problems in the world despite significant
developments in diagnostic methods and medications. Many of the conventional therapies …

A high incidence of cancer has given rise to the development of more anti-tumor drugs. From
2015 to 2020, fifty-six new small-molecule anticancer drugs, divided into ten categories …

Epidermal growth factor receptor (EGFR), a transmembrane glycoprotein that mediates
cellular signaling pathways involved in cell proliferation, angiogenesis, apoptosis, and …

Cancer cells have the ability of dysregulation and autonomous proliferation due to
unchecked production of definite molecules. These molecules are involved in the cell growth …