Patients and physicians worldwide are facing tremendous health care hazards that are
caused by the ongoing severe acute respiratory distress syndrome coronavirus 2 (SARS …

The current global health threat by the novel coronavirus disease 2019 (COVID-19) requires
an urgent deployment of advanced therapeutic options available. The role of …

This is the first of two invited articles reviewing the development of nucleoside-analogue
antiviral drugs, written for a target audience of virologists and other non-chemists, as well as …

This is the second of two invited articles reviewing the development of nucleoside analogue
antiviral drugs, written for a target audience of virologists and other non-chemists, as well as …

For many decades, the design of new nucleoside analogs as potential therapeutic agents
focused on both sugar and nucleobase modifications. These nucleoside analogs rely on …

The ongoing SARS‐CoV‐2 pandemic stresses the need for effective antiviral drugs that can
quickly be applied in order to reduce morbidity, mortality, and ideally viral transmission. By …

Although the phosphorus atom is found in a variety of oxidation states, most of the
phosphorus‐containing molecules of pharmacological importance possess phosphorus in …

COVID-19, as an emerging infectious disease, has caused significant mortality and
morbidity along with socioeconomic impact. No effective treatment or vaccine has been …

A substantial portion of metabolism involves transformation of phosphate esters, including
pathways leading to nucleotides and oligonucleotides, carbohydrates, isoprenoids and …

Following the first report on the nucleoside phosphoramidate (ProTide) prodrug approach in
1990 by Chris McGuigan, the extensive investigation of ProTide technology has begun in …