Cancer is the second leading cause of death globally. Millions of persons die due to cancer
each year. In the last two decades, the anticancer effects of natural flavonoids have become …

Apoptosis plays an essential role in homeostasis and pathogenesis of a variety of human
diseases. Endothelial cells are exposed to various environmental and internal stress and …

Pericyte-endothelial cell (EC) interactions are critical to both vascular development and
vessel stability. We have previously shown that TGF-β signaling between EC and mural cells …

Significance: Pulmonary arterial hypertension (PAH) is a progressive disease of the lung
vasculature characterized by the proliferation of all vascular wall cell types, including …

In recent years there has been an increasing appreciation of the functional heterogeneity
that exists between extraalveolar and alveolar endothelial cells. One of the most striking …

Transforming growth factor-β (TGF-β) triggers apoptosis in endothelial cells, while the
mechanisms underlying this action are not entirely understood. Using genetic and …

Altered metabolism in pulmonary artery smooth muscle cells (PASMCs) and endothelial
cells (PAECs) contributes to the pathology of pulmonary hypertension (PH), but changes in …

Cyclical formation and regression of the ovarian corpus luteum is required for reproduction.
During luteal regression, the microvasculature of the corpus luteum is extensively disrupted …

Objective—To determine whether pulmonary arterial hypertension is associated with
endothelial cell (EC)–Cav-1 (caveolin-1) depletion, EC-derived extracellular vesicle cross …

Endoglin (Eng) is an auxiliary receptor for transforming growth factor-β (TGFβ), with
important roles in vascular function. TGFβ regulates angiogenesis through balancing the pro …