The proper activities of enhancers and gene promoters are essential for coordinated
transcription within a cell. Although diverse methodologies have been developed to identify …

Abstract RNA polymerase II (Pol II) core promoters are specialized DNA sequences at
transcription start sites of protein-coding and non-coding genes that support the assembly of …

Promoters are consensus DNA sequences located near the transcription start sites and they
play an important role in transcription initiation. Due to their importance in biological …

Proteotoxic stress, that is, stress caused by protein misfolding and aggregation, triggers the
rapid and global reprogramming of transcription at genes and enhancers. Genome-wide …

Programs of gene expression are executed by a battery of transcription factors that
coordinate divergent transcription from a pair of tightly linked core initiation regions of …

Transcription initiation is a process that is essential to ensuring the proper function of any
gene, yet we still lack a unified understanding of sequence patterns and rules that explain …

Long non-coding RNAs (lncRNAs) are important biological mediators that regulate
numerous cellular processes. New experimental evidence suggests that lncRNAs play …

Despite much research, our understanding of the architecture and cis-regulatory elements of
human promoters is still lacking. Here, we devised a high-throughput assay to quantify the …

The signals that direct the initiation of transcription ultimately converge at the core promoter,
which is the gateway to transcription. Here we provide an overview of the RNA polymerase II …

Transcription termination pathways mitigate the detrimental consequences of unscheduled
promiscuous initiation occurring at hundreds of thousands of genomic cis-regulatory …