Radiation, inflammation and the immune response in cancer
Radiation is an important component of cancer treatment with more than half of all patients
receive radiotherapy during their cancer experience. While the impact of radiation on tumour …
receive radiotherapy during their cancer experience. While the impact of radiation on tumour …
Molecular mechanisms of low dose ionizing radiation-induced hormesis, adaptive responses, radioresistance, bystander effects, and genomic instability
FR Tang, WK Loke - International journal of radiation biology, 2015 - Taylor & Francis
Purposes: To review research progress on the molecular mechanisms of low dose ionizing
radiation (LDIR)-induced hormesis, adaptive responses, radioresistance, bystander effects …
radiation (LDIR)-induced hormesis, adaptive responses, radioresistance, bystander effects …
Inhibition of poly (ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models
JM Albert, C Cao, KW Kim, CD Willey, L Geng… - Clinical cancer …, 2007 - AACR
Abstract Purpose: Poly (ADP-ribose) polymerase-1 (PARP-1) is the founding member of a
family of enzymes that catalyze the addition of ADP-ribose units to proteins that mediate …
family of enzymes that catalyze the addition of ADP-ribose units to proteins that mediate …
Low-Dose Hyper-radiosensitivity: A Consequence of Ineffective Cell Cycle Arrest of Radiation-Damaged G2-Phase Cells
B Marples, BG Wouters, SJ Collis… - Radiation …, 2004 - meridian.allenpress.com
Abstract Marples, B., Wouters, BG, Collis, SJ, Chalmers, AJ and Joiner, MC Low-Dose Hyper-
radiosensitivity: A Consequence of Ineffective Cell Cycle Arrest of Radiation-Damaged G2 …
radiosensitivity: A Consequence of Ineffective Cell Cycle Arrest of Radiation-Damaged G2 …
Gene expression profiles of normal human fibroblasts after exposure to ionizing radiation: a comparative study of low and high doses
Abstract Ding, LH., Shingyoji, M., Chen, F., Hwang, JJ., Burma, S., Lee, C., Cheng, JF. and
Chen, DJ Gene Expression Profiles of Normal Human Fibroblasts after Exposure to Ionizing …
Chen, DJ Gene Expression Profiles of Normal Human Fibroblasts after Exposure to Ionizing …
General aspects of the cellular response to low-and high-LET radiation
JP Pouget, SJ Mather - European journal of nuclear medicine, 2001 - Springer
Radiobiological studies have shown for some time that the effects of ionising radiation on
cells are mainly explained by modification of the DNA. Numerous studies over the past 50 …
cells are mainly explained by modification of the DNA. Numerous studies over the past 50 …
Gene expression changes in mouse brain after exposure to low‐dose ionizing radiation
E Yin, DO Nelson, MA Coleman… - … journal of radiation …, 2003 - Taylor & Francis
Purpose: To characterize the cellular functions associated with the altered transcript profiles
of mouse brain exposed to low‐dose in vivo gamma‐irradiation. Materials and methods …
of mouse brain exposed to low‐dose in vivo gamma‐irradiation. Materials and methods …
Interrelationships amongst radiation-induced genomic instability, bystander effects, and the adaptive response
MA Kadhim, SR Moore, EH Goodwin - Mutation Research/Fundamental …, 2004 - Elsevier
Over the past two decades, our understanding of radiation biology has undergone a
fundamental shift in paradigms away from deterministic “hit–effect” relationships and …
fundamental shift in paradigms away from deterministic “hit–effect” relationships and …
Enhancement of radiation-induced oxidative stress and cytotoxicity in tumor cells by ellagic acid
SM Bhosle, NG Huilgol, KP Mishra - Clinica chimica acta, 2005 - Elsevier
BACKGROUND: Failure of treatment of cancer in clinic by radio/chemotherapy is generally
attributed to tumor resistance. It is, therefore, important to develop strategies to increase the …
attributed to tumor resistance. It is, therefore, important to develop strategies to increase the …
PARP-1, PARP-2, and the cellular response to low doses of ionizing radiation
A Chalmers, P Johnston, M Woodcock, M Joiner… - International Journal of …, 2004 - Elsevier
PURPOSE: Poly (ADP-ribose) polymerase-1 (PARP-1) is rapidly and directly activated by
single-strand breaks and is required for efficient base excision repair. These properties …
single-strand breaks and is required for efficient base excision repair. These properties …