Novel and improved biocatalysts are increasingly sourced from libraries via experimental
screening. The success of such campaigns is crucially dependent on the number of …

Directed evolution has proved to be an effective strategy for improving or altering the activity
of biomolecules for industrial, research and therapeutic applications. The evolution of …

Gene expression occurs in two essential steps: transcription and translation. In bacteria, the
two processes are tightly coupled in time and space, and highly regulated. Tight regulation …

Bacteriophage research has been instrumental to advancing many fields of biology, such as
genetics, molecular biology, and synthetic biology. Many phage-derived technologies have …

Genetic circuits and metabolic pathways can be reengineered to allow organisms to process
signals and manufacture useful chemicals. However, their functions currently rely on …

In this study, we introduce an electrochemiluminescence (ECL) sensing platform based on
the" Entropy-driven triggered T7 amplification-CRISPR/Cas13a system"(EDT-Cas). This …

Biological technologies are fundamentally unlike any other because biology evolves.
Bioengineering therefore requires novel design methodologies with evolution at their core …

Synthetic genetic sensors and circuits enable programmable control over timing and
conditions of gene expression and, as a result, are increasingly incorporated into the control …

The combination of modern biotechnologies such as DNA synthesis, λ red recombineering,
CRISPR-based editing and next-generation high-throughput sequencing increasingly …

Synthetic biology strives to reliably control cellular behavior, typically in the form of user-
designed interactions of biological components to produce a predetermined output …