Antibody responses to viral infections: a structural perspective across three different enveloped viruses
CD Murin, IA Wilson, AB Ward - Nature microbiology, 2019 - nature.com
Antibodies serve as critical barriers to viral infection. Humoral immunity to a virus is achieved
through the dual role of antibodies in communicating the presence of invading pathogens in …
through the dual role of antibodies in communicating the presence of invading pathogens in …
Antibody-mediated protection against Ebola virus
Recent Ebola virus disease epidemics have highlighted the need for effective vaccines and
therapeutics to prevent future outbreaks. Antibodies are clearly critical for control of this …
therapeutics to prevent future outbreaks. Antibodies are clearly critical for control of this …
[HTML][HTML] Systematic analysis of monoclonal antibodies against Ebola virus GP defines features that contribute to protection
Antibodies are promising post-exposure therapies against emerging viruses, but which
antibody features and in vitro assays best forecast protection are unclear. Our international …
antibody features and in vitro assays best forecast protection are unclear. Our international …
[HTML][HTML] Ebola virus epidemiology, transmission, and evolution during seven months in Sierra Leone
Summary The 2013–2015 Ebola virus disease (EVD) epidemic is caused by the Makona
variant of Ebola virus (EBOV). Early in the epidemic, genome sequencing provided insights …
variant of Ebola virus (EBOV). Early in the epidemic, genome sequencing provided insights …
Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody
Ebola virus disease in humans is highly lethal, with case fatality rates ranging from 25 to
90%. There is no licensed treatment or vaccine against the virus, underscoring the need for …
90%. There is no licensed treatment or vaccine against the virus, underscoring the need for …
[HTML][HTML] Potential neutralizing antibodies discovered for novel corona virus using machine learning
The fast and untraceable virus mutations take lives of thousands of people before the
immune system can produce the inhibitory antibody. The recent outbreak of COVID-19 …
immune system can produce the inhibitory antibody. The recent outbreak of COVID-19 …
Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak
Antibodies targeting the Ebola virus surface glycoprotein (EBOV GP) are implicated in
protection against lethal disease, but the characteristics of the human antibody response to …
protection against lethal disease, but the characteristics of the human antibody response to …
[HTML][HTML] Longitudinal analysis of the human B cell response to Ebola virus infection
Ebola virus (EBOV) remains a public health threat. We performed a longitudinal study of B
cell responses to EBOV in four survivors of the 2014 West African outbreak. Infection …
cell responses to EBOV in four survivors of the 2014 West African outbreak. Infection …
Development of clinical-stage human monoclonal antibodies that treat advanced Ebola virus disease in nonhuman primates
KE Pascal, D Dudgeon, JC Trefry… - The Journal of …, 2018 - academic.oup.com
Background For most classes of drugs, rapid development of therapeutics to treat emerging
infections is challenged by the timelines needed to identify compounds with the desired …
infections is challenged by the timelines needed to identify compounds with the desired …
[HTML][HTML] Ebola virus infection: review of the pharmacokinetic and pharmacodynamic properties of drugs considered for testing in human efficacy trials
V Madelain, THT Nguyen, A Olivo… - Clinical …, 2016 - Springer
The 2014–2015 outbreak of Ebola virus disease is the largest epidemic to date in terms of
the number of cases, deaths, and affected areas. In October 2015, no antiviral agents had …
the number of cases, deaths, and affected areas. In October 2015, no antiviral agents had …