Hepatocellular carcinoma (HCC) is a highly lethal cancer, with increasing worldwide
incidence, that is mainly associated with chronic hepatitis B virus (HBV) and/or hepatitis C …

Abstract Knowledge of the immunological events necessary to control hepatitis B virus
(HBV) infection has accelerated in recent years, but their translation towards therapeutic …

Colorectal cancer is the third most common malignancy worldwide, with 1.3 million new
cases annually. Metastasis to the liver is a leading cause of mortality in these patients. In …

Objective A comprehensive immune landscape for HBV infection is pivotal to achieve HBV
cure. Design We performed single-cell RNA sequencing of 2 43 000 cells from 46 paired …

Rationale The liver-specific natural killer (NK) cell population is critical for local innate
immune responses, but the mechanisms that lead to their selective homing and the …

Hepatitis B virus (HBV) is a hepatotropic virus and an important human pathogen. There are
an estimated 296 million people in the world that are chronically infected by this virus, and …

Natural killer (NK) cells are enriched in lymphocytes within the liver and have unique
phenotypic features and functional properties, including tumor necrosis factor–related …

Natural killer (NK) cell activation is well orchestrated by a wide array of NK cell receptor
repertoire. T-cell immunoglobulin and ITIM domain (TIGIT) receptor was recently defined as …

In this review we give a brief update on sensors recently determined to be capable of
detecting HBV, and examine how the virus represses the induction of pro-inflammatory …

Interleukin-15 (IL-15) is a pleiotropic cytokine with a broad range of biological functions in
many diverse cell types. It plays a major role in the development of inflammatory and …