Clinical epigenetics: seizing opportunities for translation
M Berdasco, M Esteller - Nature Reviews Genetics, 2019 - nature.com
Biomarker discovery and validation are necessary for improving the prediction of clinical
outcomes and patient monitoring. Despite considerable interest in biomarker discovery and …
outcomes and patient monitoring. Despite considerable interest in biomarker discovery and …
Epigenome-wide association studies: current knowledge, strategies and recommendations
The aetiology and pathophysiology of complex diseases are driven by the interaction
between genetic and environmental factors. The variability in risk and outcomes in these …
between genetic and environmental factors. The variability in risk and outcomes in these …
DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis
The human leukocyte antigen (HLA) haplotype DRB1* 15: 01 is the major risk factor for
multiple sclerosis (MS). Here, we find that DRB1* 15: 01 is hypomethylated and …
multiple sclerosis (MS). Here, we find that DRB1* 15: 01 is hypomethylated and …
A systematic review of smoking-related epigenetic alterations
The aim of this study is to provide a systematic review of the known epigenetic alterations
caused by cigarette smoke; establish an evidence-based perspective of their clinical value …
caused by cigarette smoke; establish an evidence-based perspective of their clinical value …
[HTML][HTML] Polypharmacy in multiple sclerosis: current knowledge and future directions
J Thelen, V Zvonarev, S Lam, C Burkhardt… - Missouri …, 2021 - ncbi.nlm.nih.gov
Polypharmacy, or the daily use of five or more medications, is well documented in older
adults and linked to negative outcomes such as medication errors, adverse drug reactions …
adults and linked to negative outcomes such as medication errors, adverse drug reactions …
From methylation to myelination: epigenomic and transcriptomic profiling of chronic inactive demyelinated multiple sclerosis lesions
In the progressive phase of multiple sclerosis (MS), the hampered differentiation capacity of
oligodendrocyte precursor cells (OPCs) eventually results in remyelination failure. We have …
oligodendrocyte precursor cells (OPCs) eventually results in remyelination failure. We have …
Smoking induces DNA methylation changes in Multiple Sclerosis patients with exposure-response relationship
Cigarette smoking is an established environmental risk factor for Multiple Sclerosis (MS), a
chronic inflammatory and neurodegenerative disease, although a mechanistic basis …
chronic inflammatory and neurodegenerative disease, although a mechanistic basis …
[PDF][PDF] Epidemiologie der Multiplen Sklerose–eine populationsbasierte deutschlandweite Studie
J Holstiege, A Steffen, B Goffrier… - Zentralinstitut für die …, 2017 - versorgungsatlas.de
Hintergrund: Die Multiple Sklerose (MS) ist die häufigste Autoimmunerkrankung des
zentralen Nervensystems. Für Deutschland wurde die Diagnoseprävalenz in der …
zentralen Nervensystems. Für Deutschland wurde die Diagnoseprävalenz in der …
Personalising surgical treatments for glaucoma patients
GS Megevand, AM Bron - Progress in Retinal and Eye Research, 2021 - Elsevier
Surgical treatments for glaucoma have relied for decades on traditional filtering surgery such
as trabeculectomy and, in more challenging cases, tubes. Antifibrotics were introduced to …
as trabeculectomy and, in more challenging cases, tubes. Antifibrotics were introduced to …
Biochemical differences in cerebrospinal fluid between secondary progressive and relapsing–remitting multiple sclerosis
To better understand the pathophysiological differences between secondary progressive
multiple sclerosis (SPMS) and relapsing-remitting multiple sclerosis (RRMS), and to identify …
multiple sclerosis (SPMS) and relapsing-remitting multiple sclerosis (RRMS), and to identify …