Organic Bioelectronics for In Vitro Systems

C Pitsalidis, AM Pappa, AJ Boys, Y Fu… - Chemical …, 2021 - ACS Publications
Bioelectronics have made strides in improving clinical diagnostics and precision medicine.
The potential of bioelectronics for bidirectional interfacing with biology through continuous …

International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes

A Bal-Price, KM Crofton, M Leist, S Allen, M Arand… - Archives of …, 2015 - Springer
A major problem in developmental neurotoxicity (DNT) risk assessment is the lack of
toxicological hazard information for most compounds. Therefore, new approaches are being …

Design and demonstration of an intracortical probe technology with tunable modulus

DM Simon, H Charkhkar, C St. John… - … Research Part A, 2017 - Wiley Online Library
Intracortical probe technology, consisting of arrays of microelectrodes, offers a means of
recording the bioelectrical activity from neural tissue. A major limitation of existing …

Ruthenium oxide based microelectrode arrays for in vitro and in vivo neural recording and stimulation

R Atmaramani, B Chakraborty, RT Rihani, J Usoro… - Acta biomaterialia, 2020 - Elsevier
We have characterized the in vitro and in vivo extracellular neural recording and stimulation
properties of ruthenium oxide (RuOx) based microelectrodes. Cytotoxicity and functional …

The potential of in vitro neuronal networks cultured on micro electrode arrays for biomedical research

M Cerina, MC Piastra, M Frega - Progress in Biomedical …, 2023 - iopscience.iop.org
In vitro neuronal models have become an important tool to study healthy and diseased
neuronal circuits. The growing interest of neuroscientists to explore the dynamics of …

Improving the performance of poly (3, 4-ethylenedioxythiophene) for brain–machine interface applications

HS Mandal, GL Knaack, H Charkhkar, DG McHail… - Acta biomaterialia, 2014 - Elsevier
Abstract Conducting polymers, especially poly (3, 4-ethylenedioxythiophene)(PEDOT)
based materials, are important for developing highly sensitive and microscale neural …

Adult mouse sensory neurons on microelectrode arrays exhibit increased spontaneous and stimulus-evoked activity in the presence of interleukin-6

BJ Black, R Atmaramani, R Kumaraju… - Journal of …, 2018 - journals.physiology.org
Following inflammation or injury, sensory neurons located in the dorsal root ganglia (DRG)
may exhibit increased spontaneous and/or stimulus-evoked activity, contributing to chronic …

Liquid crystal elastomer-based microelectrode array for in vitro neuronal recordings

RT Rihani, H Kim, BJ Black, R Atmaramani, MO Saed… - Micromachines, 2018 - mdpi.com
Polymer-based biomedical electronics provide a tunable platform to interact with nervous
tissue both in vitro and in vivo. Ultimately, the ability to control functional properties of neural …

Amyloid beta modulation of neuronal network activity in vitro

H Charkhkar, S Meyyappan, E Matveeva, JR Moll… - Brain research, 2015 - Elsevier
In vitro assays offer a means of screening potential therapeutics and accelerating the drug
development process. Here, we utilized neuronal cultures on planar microelectrode arrays …

Copper–Ruthenium Composite as Perspective Material for Bioelectrodes: Laser-Assisted Synthesis, Biocompatibility Study, and an Impedance-Based Cellular …

DD Stupin, AA Abelit, AS Mereshchenko, MS Panov… - Biosensors, 2022 - mdpi.com
Copper is an inexpensive material that has found wide application in electronics due to its
remarkable electric properties. However, the high toxicity of both copper and copper oxide …