Acute chest syndrome (ACS) is a frequent cause of acute lung disease in children with sickle
cell disease (SCD). Patients may present with ACS or may develop this complication during …

Acute chest syndrome (ACS) is a common complication and reason for hospital admission in
patients with sickle cell disease (SCD). It is also the most common cause of death in this …

Sickle cell disease (SCD) is a complex, clinically heterogeneous disorder affecting
approximately 100,000 individuals in the United States and millions worldwide. The disease …

Introduction: the spectrum of pulmonary complications in sickle cell anemia (SCA) comprises
mainly of acute chest syndrome (ACS), pulmonary hypertension (PH) and Airway hyper …

Background: Pulmonary complications of sickle cell disease (SCD) are diverse and
encompass acute and chronic disease. The understanding of the natural history of …

Acute chest syndrome is a frequent cause of acute lung disease in children with sickle-cell
disease. Asthma is common in children with sickle-cell disease and is associated with …

Introduction Sickle cell disease, one of the world's most prevalent Mendelian disorders, is a
chronic hemolytic anemia punctuated by acute vasoocclusive events. Both hemolysis and …

Sickle cell disease (SCD), the most common genetic hemolytic anemia worldwide, affects
250,000 births annually. In the United States, SCD affects approximately 100,000 …

Hypoxemia is common in SCD and likely exacerbates SCD vasculopathy. Pulse oximeter
correlation with arterial oxygen tension in patients with SCD may at times be poor and …

Background The high prevalence of airway hyperresponsiveness (AHR) among children
with sickle cell anemia (SCA) remains unexplained. Methods To determine the relationship …