The study explored a modified primary culture system for fetal rat cortical neurons. Day E18
embryos from pregnant Sprague Dawley rats were microdissected under a stereoscope. To …

Carbon ion radiotherapy holds great promise for cancer therapy. Clinical data show that
carbon ion radiotherapy is an effective treatment for tumors that are resistant to X-ray …

The aim of this study was to investigate whether melatonin, a free radical scavenger and a
general antioxidant, regulates the brain cell apoptosis caused by carbon ions in mice at the …

All living organisms and ecosystems are permanently exposed to ionizing radiation. Of all
the types of ionizing radiation, heavy ions such as 56 Fe have the potential to cause the …

The effects of X-irradiation on developing neurons and their functions are unclear. We used
primary cultures of mouse hippocampal neurons to investigate the effects of X-irradiation on …

Objective: To investigate whether the intermittent hypothermia (IH) protects neurons against
ischemic insult and the potential molecular targets using an in vitro ischemic model of …

ΔNp73 has emerged as an interesting novel factor in cancer research. Here, we report the
effect of carbon-ion beams on ΔNp73 expression in human cervix carcinoma HeLa cells in …

To clarify the relative biological effectiveness (RBE) values of carbon ion (C) beams in
normal brain tissues, a rat organotypic slice culture system was used. The cerebellum was …

Purpose: To investigate the interaction of the cytotoxic activity of the combination of
pemetrexed and radiation in a human mesothelioma cell line. Materials and Methods: The …

Radiation therapy is an essential tool in the cure of many cancer patients. Charged particle
based radiation therapies are gaining momentum as the physical dose distributions of ions …