A potentially important aspect in the regulation of tumour metastasis is endocytosis. This
process consists of internalisation of cell-surface receptors via pinocytosis, phagocytosis or …

Alternaria molds are known to cause the contamination of food with their secondary
metabolites, a chemically very heterogeneous group of compounds. Yet, after decades of …

An essential property of the plasma membrane of mammalian cells is its plasticity, which is
required for sensing and transmitting of signals, and for accommodating the tensional …

In development, wound healing, and cancer metastasis, vertebrate cells move through 3D
interstitial matrix, responding to chemical and physical guidance cues. Protrusion at the cell …

Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a signalling
network known as the unfolded protein response (UPR). Here, we identified filamin A as a …

Early in cancer development, tumour cells express vascular endothelial growth factor
(VEGF), a secreted molecule that is important in all stages of angiogenesis, an essential …

At the time of diagnosis, 20% of patients with colorectal cancer present metastasis. Among
individuals with primary lesions, 50% of them will develop distant tumours with time …

Cancer cells are subjected to fluid shear stress during passage through the venous and
lymphatic system. Caveolin-1 (Cav-1), a principal structural component of caveolar …

Abstract Caveolin-1 (CAV1) is commonly considered to function as a cell surface protein, for
instance in the genesis of caveolae. Nonetheless, it is also present in many intracellular …

Breast cancer is one of the most frequently diagnosed cancers and the leading cause of
cancer-related deaths in women worldwide, whereby mortality is largely attributable to the …