The replacement of para-substituted benzenes with saturated bi-and polycyclic bioisosteres–
bicyclo [1.1. 1] pentane, bicyclo [2.2. 2] octane and cubane,–often increases the potency …

At first sight the application of 19F NMR to biological samples may seem like a paradox, as
fluorine scarcely occurs in organic matter. However, this very lack of natural abundance in …

Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were
used to examine the ultrastructural changes in bacteria induced by antimicrobial peptides …

The larvae of the common green bottle fly (Lucilia sericata) produce antibacterial secretions
that have a therapeutic effect on chronic and nonhealing wounds. Recent developments in …

We used solid-state NMR spectroscopy to investigate the oligomeric structure and insertion
of protegrin-1 (PG-1), a β-hairpin antimicrobial peptide, in lipid bilayers that mimic either the …

An endophytic fungus (Botryosphaeria rhodina) was isolated from the stems of the medicinal
plant Bidens pilosa (Asteraceae) that is known for its anti-inflammatory, antiseptic and …

There is some overlap in the biological activities of cell-penetrating peptides (CPPs) and
antimicrobial peptides (AMPs). We compared nine AMPs, seven CPPs, and a fusion peptide …

NMR is a versatile tool for studying interactions between antimicrobial peptides and lipid
membranes. Different approaches using both liquid state and solid state NMR are outlined …

Multidrug-resistant Pseudomonas aeruginosa is a major cause of severe hospital-acquired
infections. Currently, polymyxin B (PMB) is a last-resort antibiotic for the treatment of …

The membrane alignment of the amphiphilic α-helical model peptide MSI-103 (sequence
[KIAGKIA] 3-NH2) was examined by solid state 2H-NMR in different lipid systems by …