Immune dysregulation is an important component of the pathophysiology of COVID-19. A
large body of literature has reported the effect of immune-based therapies in patients with …

Children and adolescents infected with severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) are predominantly asymptomatic or have mild symptoms compared with the …

Importance Refinement of criteria for multisystem inflammatory syndrome in children (MIS-C)
may inform efforts to improve health outcomes. Objective To compare clinical characteristics …

Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that
follows benign COVID-19. We report autosomal recessive deficiencies of OAS1, OAS2, or …

Children and adolescents exhibit a broad range of clinical outcomes from SARS-CoV-2
infection, with the majority having minimal to mild symptoms. Additionally, some succumb to …

The rapid spread of coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome–coronavirus 2 (SARS-CoV-2), has resulted in an unprecedented …

Background The assessment of real-world effectiveness of immunomodulatory medications
for multisystem inflammatory syndrome in children (MIS-C) may guide therapy. Methods We …

Multisystem inflammatory syndrome (MIS-C) is a pediatric hyperinflammation disorder
caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). It has now been …

An association between a novel pediatric hyperinflammatory condition and SARS-CoV-2
was recently published and termed pediatric inflammatory multisystem syndrome, temporally …

It is not fully understood why COVID-19 is typically milder in children,–. Here, to examine the
differences between children and adults in their response to SARS-CoV-2 infection, we …