The introduction of high-resolution time lapse imaging and molecular biological tools has
changed dramatically the rate of progress towards the understanding of the complex …

G protein-coupled receptors (GPCRs) mediate physiological responses to various ligands,
such as hormones, neurotransmitters and sensory stimuli. The signalling and trafficking …

G-protein-coupled receptors (GPCRs) represent one of the largest gene families in the
animal genome. These receptors can be classified into several groups based on the …

The Homer family of adaptor proteins consists of three members in mammals, and homologs
are also known in other animals but not elsewhere. They are predominantly localized at the …

Homeostatic scaling is a non-Hebbian form of neural plasticity that maintains neuronal
excitability and informational content of synaptic arrays in the face of changes of network …

A growing body of evidence indicates that repeated exposure to cocaine leads to profound
changes in glutamate transmission in limbic nuclei, particularly the nucleus accumbens. This …

G protein-coupled receptors (GPCRs) constitute a superfamily of cell-surface receptors
which share a common topology of seven transmembrane domains and modulate a variety …

The mammalian brain is plastic in the sense that it shows a remarkable capacity for change
throughout life. The contribution of neuronal activity to brain plasticity was first recognized in …

Group I metabotropic glutamate receptors (mGluRs) increase cellular levels of inositol-1, 4, 5-
triphosphate (IP3) and thereby trigger intracellular Ca2+ release. Also, group I mGluRs are …

A synaptic tag transiently marks a synapse after activation in a way that allows the local
recognition of transcriptional products to effect an enduring change in transmission …