Coumarins and P450s, studies reported to-date
M Foroozesh, J Sridhar, N Goyal, J Liu - Molecules, 2019 - mdpi.com
Cytochrome P450 enzymes (CYPs) are important phase I enzymes involved in the
metabolism of endogenous and xenobiotic compounds mainly through mono-oxygenation …
metabolism of endogenous and xenobiotic compounds mainly through mono-oxygenation …
Four decades of Cytochrome P450 2B research: from protein adducts to protein structures and beyond
AG Roberts, JC Stevens, GD Szklarz, EE Scott… - Drug Metabolism and …, 2023 - ASPET
This article features selected findings from the senior author and colleagues dating back to
1978 and covering approximately three-fourths of the 60 years since the discovery of …
1978 and covering approximately three-fourths of the 60 years since the discovery of …
Halogen− π interactions in the cytochrome P450 active site: Structural insights into human CYP2B6 substrate selectivity
Numerous cytochrome P450 (CYP) 2B6 substrates including drugs and environmental
chemicals are halogenated. To assess the role of halogen− π bonds in substrate selectivity …
chemicals are halogenated. To assess the role of halogen− π bonds in substrate selectivity …
Trio‐binned genomes of the woodrats Neotoma bryanti and Neotoma lepida reveal novel gene islands and rapid copy number evolution of xenobiotic metabolizing …
The genomic architecture underlying the origins and maintenance of biodiversity is an
increasingly accessible feature of species, due in large part to third‐generation sequencing …
increasingly accessible feature of species, due in large part to third‐generation sequencing …
Ionic liquid-functionalized magnetic nanostructures as an efficient catalyst for the synthesis of 6H-chromeno [4, 3-b] quinolin-6-ones
G Rahimzadeh, S Bahadorikhalili, E Kianmehr… - Molecular Diversity, 2017 - Springer
A novel imidazole ionic liquid (IL)-functionalized silica@ γ silica@ γ-Fe _ 2 O _ 3 Fe 2 O 3 (IL-
SiO _ 2@ MNP IL-SiO 2@ MNP) is prepared by the functionalization of SiO _ 2@ MNP SiO …
SiO _ 2@ MNP IL-SiO 2@ MNP) is prepared by the functionalization of SiO _ 2@ MNP SiO …
Multidisciplinary Insights into the Structure–Function Relationship of the CYP2B6 Active Site
ED Angle, PM Cox - Drug Metabolism and Disposition, 2023 - ASPET
Cytochrome P450 2B6 (CYP2B6) is a highly polymorphic human enzyme involved in the
metabolism of many clinically relevant drugs, environmental toxins, and endogenous …
metabolism of many clinically relevant drugs, environmental toxins, and endogenous …
Structure of cytochrome P450 2C9* 2 in complex with losartan: insights into the effect of genetic polymorphism
The human CYP2C9 plays a crucial role in the metabolic clearance of a wide range of
clinical therapeutics. The* 2 allele is a prevalent genetic variation in CYP2C9 that is found in …
clinical therapeutics. The* 2 allele is a prevalent genetic variation in CYP2C9 that is found in …
Role of cytochrome P450 2B sequence variation and gene copy number in facilitating dietary specialization in mammalian herbivores
Abstract Theory postulates that dietary specialization in mammalian herbivores is enabled
by a specialized set of liver enzymes that process the high concentrations of similar plant …
by a specialized set of liver enzymes that process the high concentrations of similar plant …
Strategies in herbivory by mammals revisited: The role of liver metabolism in a juniper specialist (Neotoma stephensi) and a generalist (Neotoma albigula)
TJ Orr, S Kitanovic, KM Schramm… - Molecular …, 2020 - Wiley Online Library
Although herbivory is widespread among mammals, few species have adopted a strategy of
dietary specialization. Feeding on a single plant species often exposes herbivores to high …
dietary specialization. Feeding on a single plant species often exposes herbivores to high …
Coumarin derivatives as substrate probes of mammalian cytochromes P450 2B4 and 2B6: assessing the importance of 7-alkoxy chain length, halogen substitution …
Using a combined structural and biochemical approach, the functional importance of a
recently described peripheral pocket bounded by the E-, F-, G-, and I-helices in CYP2B4 and …
recently described peripheral pocket bounded by the E-, F-, G-, and I-helices in CYP2B4 and …