Amphibole asbestos as an environmental trigger for systemic autoimmune diseases

JC Pfau, B McLaurin, BJ Buck, FW Miller - Autoimmunity Reviews, 2024 - Elsevier
A growing body of evidence supports an association between systemic autoimmune disease
and exposure to amphibole asbestos, a form of asbestos typically with straight, stiff, needle …

To eat or not to eat—An exploratory randomized controlled trial on fasting and plant-based diet in rheumatoid arthritis (NutriFast-Study)

AM Hartmann, M Dell'Oro, M Spoo, JM Fischer… - Frontiers in …, 2022 - frontiersin.org
Background Fasting is beneficial in many diseases, including rheumatoid arthritis (RA), with
lasting effects for up to 1 year. However, existing data dates back several decades before …

Centrality of myeloid-lineage phagocytes in particle-triggered inflammation and autoimmunity

OK Favor, JJ Pestka, MA Bates, KSS Lee - Frontiers in Toxicology, 2021 - frontiersin.org
Exposure to exogenous particles found as airborne contaminants or endogenous particles
that form by crystallization of certain nutrients can activate inflammatory pathways and …

Lipidome modulation by dietary omega-3 polyunsaturated fatty acid supplementation or selective soluble epoxide hydrolase inhibition suppresses rough LPS …

OK Favor, PS Chauhan, E Pourmand… - Frontiers in …, 2023 - frontiersin.org
Introduction Lipopolysaccharide (LPS)-accelerated autoimmune glomerulonephritis (GN) in
NZBWF1 mice is a preclinical model potentially applicable for investigating lipidome …

Rapid induction of pulmonary inflammation, autoimmune gene expression, and ectopic lymphoid neogenesis following acute silica exposure in lupus-prone mice

PS Chauhan, JG Wagner, AD Benninghoff… - Frontiers in …, 2021 - frontiersin.org
Occupational exposure to crystalline silica (cSiO2) is etiologically associated with systemic
lupus erythematosus (lupus) and other autoimmune diseases. cSiO2's autoimmune effects …

Omega-3 polyunsaturated fatty acid intervention against established autoimmunity in a murine model of toxicant-triggered lupus

JJ Pestka, P Akbari, KA Wierenga, MA Bates… - Frontiers in …, 2021 - frontiersin.org
Workplace exposure to respirable crystalline silica dust (cSiO2) has been etiologically linked
to the development of lupus and other human autoimmune diseases. Lupus triggering can …

Requisite omega-3 HUFA biomarker thresholds for preventing murine lupus flaring

KA Wierenga, RS Strakovsky, AD Benninghoff… - Frontiers in …, 2020 - frontiersin.org
Lupus is a systemic autoimmune disease typified by uncontrolled inflammation, disruption of
immune tolerance, and intermittent flaring–events triggerable by environmental factors …

Results from omic approaches in rat or mouse models exposed to inhaled crystalline silica: a systematic review

L Morin, V Lecureur, A Lescoat - Particle and Fibre Toxicology, 2024 - Springer
Background Crystalline silica (cSiO2) is a mineral found in rocks; workers from the
construction or denim industries are particularly exposed to cSiO2 through inhalation. cSiO2 …

Comparative effects of human-equivalent low, moderate, and high dose oral prednisone intake on autoimmunity and glucocorticoid-related toxicity in a murine model …

LK Heine, AD Benninghoff, EA Ross… - Frontiers in …, 2022 - frontiersin.org
Autoimmune diseases can be triggered by environmental toxicants such as crystalline silica
dust (cSiO2). Here, we characterized the dose-dependent immunomodulation and toxicity of …

Omega-3 docosahexaenoic acid (DHA) impedes silica-induced macrophage corpse accumulation by attenuating cell death and potentiating efferocytosis

LD Rajasinghe, PS Chauhan, KA Wierenga… - Frontiers in …, 2020 - frontiersin.org
Airway exposure of lupus-prone NZBWF1 mice to crystalline silica (cSiO2), a known trigger
of human autoimmune disease, elicits sterile inflammation and alveolar macrophage death …