Aducanumab (aducanumab-avwa; Aduhelm™) is a human, immunoglobulin gamma 1
(IgG1) monoclonal antibody directed against aggregated soluble and insoluble forms of …

Protein aggregation is common to dozens of diseases including prionoses, diabetes,
Parkinson's and Alzheimer's. Over the past 15 years, there has been a paradigm shift in …

Alzheimer's disease (AD) is considered to be the most common cause of dementia and is an
incurable, progressive neurodegenerative disorder. Current treatment of the disease …

The aggregation of specific proteins is hypothesized to underlie several degenerative
diseases, which are collectively known as amyloid disorders. However, the mechanistic …

Alzheimer's disease (AD) is a debilitating neurodegenerative disease that is affecting an
increasing number of people. It is characterized by the accumulation of amyloid-β and tau …

Alzheimer's disease (AD) is the most prevalent form of dementia worldwide and is an
emerging global epidemic. It is characterized by an imbalance between production and …

The ε4 allele of the apolipoprotein E gene (APOE4) is associated with cognitive decline
during aging, is the greatest genetic risk factor for Alzheimer's disease and has links to other …

Misfolded proteins (MP) are a key component in aging and associated neurodegenerative
disorders. For example, misfolded Amyloid-ß (Aß) and tau proteins are two neuropathogenic …

A genuine and functional lymphatic vascular system is found in the meninges that sheath the
central nervous system (CNS). This unexpected (re) discovery led to a reevaluation of CNS …

Sleep–wake disturbances are a highly prevalent and often disabling feature of Alzheimer's
disease (AD). A cardinal feature of AD includes the formation of amyloid plaques, associated …