1, 3, 4-thiadiazole: A privileged scaffold for drug design and development
X Han, YL Yu, YS Hu, XH Liu - Current Topics in Medicinal …, 2021 - ingentaconnect.com
1, 3, 4-thiadiazole is a five-membered aromatic heterocycle containing two nitrogen atoms
and one sulfur atom. As a privileged scaffold, it has its unique chemical properties and …
and one sulfur atom. As a privileged scaffold, it has its unique chemical properties and …
Antioxidant compounds in the treatment of Alzheimer's disease: Natural, hybrid, and synthetic products
M Hatami, M Mortazavi, Z Baseri… - Evidence‐Based …, 2023 - Wiley Online Library
Alzheimer's disease (AD) which is associated with cognitive dysfunction and memory lapse
has become a health concern. Various targets and pathways have been involved in AD's …
has become a health concern. Various targets and pathways have been involved in AD's …
Design and development of some phenyl benzoxazole derivatives as a potent acetylcholinesterase inhibitor with antioxidant property to enhance learning and …
Based on the Gaussian-based quantitative structure-activity relationship (QSAR) and virtual
screening (VS) processes, some promising acetylcholinesterase inhibitors (AChEIs) having …
screening (VS) processes, some promising acetylcholinesterase inhibitors (AChEIs) having …
Biphenyl-3-oxo-1, 2, 4-triazine linked piperazine derivatives as potential cholinesterase inhibitors with anti-oxidant property to improve the learning and memory
A series of novel piperazine tethered biphenyl-3-oxo-1, 2, 4-triazine derivatives were
designed, and synthesized. Amongst the synthesized analogs, compound 6g showed …
designed, and synthesized. Amongst the synthesized analogs, compound 6g showed …
Thiadiazole–A promising structure in design and development of anti-Alzheimer agents
M Hatami, Z Basri, BK Sakhvidi, M Mortazavi - International …, 2023 - Elsevier
The design and development of effective multitargeted agents in treating Alzheimer disease
(AD) has always been a hot topic in the field of drug discovery. Since AD is a multifactorial …
(AD) has always been a hot topic in the field of drug discovery. Since AD is a multifactorial …
Design and development of 1, 3, 4-oxadiazole derivatives as potential inhibitors of acetylcholinesterase to ameliorate scopolamine-induced cognitive dysfunctions
The novel hybrids bearing 4-aminopyridine (4-AP) tethered with substituted 1, 3, 4-
oxadiazole nucleus were designed, synthesized, and evaluated for their potential AChE …
oxadiazole nucleus were designed, synthesized, and evaluated for their potential AChE …
Design, synthesis and biological assessment of acridine derivatives containing 1, 3, 4-thiadiazole moiety as novel selective acetylcholinesterase inhibitors
A novel series of acridine derivatives containing substituted thiadiazol-2-amine moiety was
synthesized via multi-component condensation reaction of dimedone, aromatic aldehyde …
synthesized via multi-component condensation reaction of dimedone, aromatic aldehyde …
Evaluation of antibacterial, antioxidant, cytotoxic, and acetylcholinesterase inhibition activities of novel [1, 4] benzoxazepines fused to heterocyclic systems with a …
Microbial pathogenesis, cancer progression, and neurological diseases are associated with
oxidative stress due to the increased production of reactive oxygen species (ROS). This …
oxidative stress due to the increased production of reactive oxygen species (ROS). This …
Isosteroidal alkaloids as potent dual-binding site inhibitors of both acetylcholinesterase and butyrylcholinesterase from the bulbs of Fritillaria walujewii
YM Liu, YD Feng, X Lu, JB Nie, W Li, LN Wang… - European Journal of …, 2017 - Elsevier
Five new isosteroidal alkaloids, walujewine A (1), walujewine B (4), walujewine C (5),
walujewine D (6), walujewine E (10) were isolated from the bulbs of Fritillaria walujewii …
walujewine D (6), walujewine E (10) were isolated from the bulbs of Fritillaria walujewii …
Kai Xin San ameliorates scopolamine-induced cognitive dysfunction
YM Xu, XC Wang, TT Xu, HY Li, SY Hei… - Neural Regeneration …, 2019 - journals.lww.com
Abstract Kai Xin San (KXS, containing ginseng, hoelen, polygala, and acorus), a traditional
Chinese herbal compound, has been found to regulate cognitive dysfunction; however, its …
Chinese herbal compound, has been found to regulate cognitive dysfunction; however, its …