The endocannabinoid system (ECS) is one of the most crucial systems in the human
organism, exhibiting multi-purpose regulatory character. It is engaged in a vast array of …

Despite the importance of pain as a warning physiological system, chronic neuropathic pain
is frequently caused by damage in the nervous system, followed by persistence over a long …

This preliminary clinical investigation of the pharmacokinetic behavior of the main
metamizole (dipyrone) metabolites 4-methylaminoantipyrine (4-MAA) and 4-aminoantipyrine …

Cannabinoid receptor type 1 (CB1) is an important modulator of many key physiological
functions and thus a compelling molecular target. However, safe CB1 targeting is a non …

Objectives The aim of this study was to evaluate the effects of dipyrone and tramadol, used
for 5 days, on postoperative pain, hematological and biochemical parameters, and oxidative …

Objective To review the literature in human and veterinary medicine regarding the
indications for, efficacy of, and controversies surrounding glucocorticoid (GC) administration …

BACKGROUND There is growing evidence that the analgesic effect of metamizole is
mediated at least partly by central mechanisms, including the endocannabinoid …

Non-steroidal anti-inflammatory drugs produce antinociceptive effects mainly through
peripheral cyclooxygenase inhibition. In opposition to the classical non-steroidal anti …

Metamizole (MT), an analgesic and antipyretic drug, is rapidly hydrolyzed to the active
primary metabolite 4‐methylaminoantipyrine (MAA) and relatively active secondary …

Background: Although medications should only be prescribed in pregnancy if benefits to the
mother outweigh the risk to the fetus, drug use in pregnancy especially prescribed and over …