The liver is a key organ that plays a pivotal role in metabolism and ensures a variety of
functions in the body, including homeostasis, synthesis of essential components, nutrient …

Landfill leachate is a complex mixture characterized by high toxicity and able to contaminate
soils and waters surrounding the dumpsite, especially in developing countries where …

Hepatoma cell lines are frequently used as in vitro alternatives to primary human
hepatocytes. Cell lines are characterized by their unlimited life span, stable phenotype, high …

Acute liver failure can be the consequence of various etiologies, with most cases arising
from drug-induced hepatotoxicity in Western countries. Despite advances in this field, the …

Non-alcoholic fatty liver disease encompasses a spectrum of liver diseases, including
simple steatosis, steatohepatitis, liver fibrosis and cirrhosis and hepatocellular carcinoma …

Introduction: The liver is the most important target for drug-induced toxicity. This vulnerability
results from functional liver features and its role in the metabolic elimination of most drugs …

Animal testing is still the most popular preclinical assessment model for liver fibrosis. To
develop efficient anti-fibrotic therapies, robust and representative in vitro models are …

Background: Drug-induced Liver Injury (DILI) is an important cause of acute liver failure
cases in the United States, and remains a common cause of withdrawal of drugs in both …

Idiosyncratic drug-induced liver injury (iDILI) encompasses the unexpected harms that
prescription and non-prescription drugs, herbal and dietary supplements can cause to the …

Glucuronidation is an important metabolic pathway for many small endogenous and
exogenous lipophilic compounds, including bilirubin, steroid hormones, bile acids …