In kidney disease, the progressive loss of renal capacity to produce calcitriol, the vitamin D
hormone, is a key contributor to elevations in parathyroid hormone (PTH) and mineral and …

Chronic Kidney Disease–Mineral and Bone Disorder (CKD-MBD) comprises alterations in
calcium, phosphorus, parathyroid hormone (PTH), Vitamin D, and fibroblast growth factor-23 …

Patients with chronic kidney disease (CKD) are given calcium carbonate to bind dietary
phosphorus, reduce phosphorus retention, and prevent negative calcium balance; however …

Vitamin D plays an essential role in calcium and inorganic phosphate (Pi) homeostasis,
maintaining their optimal levels to assure adequate bone mineralization. Vitamin D, as …

Bone biology is physiologically complex and intimately linked to calcium homeostasis. The
literature provides a wealth of qualitative and/or quantitative descriptions of cellular …

Current treatment of secondary hyperparathyroidism in chronic kidney failure with calcium
and active vitamin D is potentially limited by hypercalcemia and hyperphosphatemia. AMG …

Results At baseline, prescribed daily phosphate was restricted to levels≤ 870, 871 to 999,
1000, 1001 to 2000 mg, and not restricted in 300, 314, 307, 297, and 533 participants …

In chronic kidney disease (CKD), abnormalities in vitamin D metabolism contribute to the
development of mineral and skeletal disorders, elevations in parathyroid hormone (PTH) …

The linear sequence of intact mammalian PTH consists of 84 amino acids, of which only the
most amino (N)-terminal portion, ie PTH-(1-34), is required for the classical actions of the …

Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) is a newly defined syndrome
encompassing patients with chronic kidney disease that have a triad of biochemical …