The maturation of the central nervous system's (CNS's) sensory connectivity is driven by
modality-specific sensory input in early life. For the somatosensory system, this input is the …

Bacterial products can act on neurons to alter signaling and function. In the present study,
we found that dorsal root ganglion (DRG) sensory neurons are enriched for ANTXR2, the …

The most superficial layer of the spinal dorsal horn, lamina I, is a key element of the
nociceptive processing system. It contains different types of projection neurons (PNs) and …

Rats with complete spinal cord transection (SCT) can recover hindlimb locomotor function
under strategies combining exercise training and 5-HT agonist treatment. This recovery is …

The periaqueductal gray (PAG) represents a key target of projection neurons residing in the
spinal dorsal horn. In comparison to lamina I spinoparabrachial neurons, little is known …

The dorsal horn of the spinal cord represents the first relay station in the pain pathway where
primary nociceptive inputs are modulated by local circuits and by descending signals before …

Key points The transient receptor potential vanilloid type 1 (TRPV1) receptor is a polymodal
molecular integrator in the pain pathway expressed in Aδ‐and C‐fibre nociceptors and is …

The rostroventral medial medulla (RVM) is part of a rapidly acting spino-bulbo-spinal loop
that is activated by ascending nociceptive inputs and drives descending feedback …

Spinal lamina I projection neurons serve as a major conduit by which noxious stimuli
detected in the periphery are transmitted to nociceptive circuits in the brain, including the …

Spontaneous activity refers to the firing of action potentials by neurons in the absence of
external stimulation. Initially considered an artifact or “noise” in the nervous system, it is now …