Lymphatic vessel: origin, heterogeneity, biological functions, and therapeutic targets
Z Hu, X Zhao, Z Wu, B Qu, M Yuan, Y Xing… - … and Targeted Therapy, 2024 - nature.com
Lymphatic vessels, comprising the secondary circulatory system in human body, play a
multifaceted role in maintaining homeostasis among various tissues and organs. They are …
multifaceted role in maintaining homeostasis among various tissues and organs. They are …
Nectin cell adhesion molecule-4 (NECTIN-4): a potential target for cancer therapy
Abstract NECTIN-4 [a poliovirus receptor-related-4 (pvrl-4) encoded protein] is a Ca 2+
independent immunoglobulin-like protein. Along with other Nectins (Nectin-1,-2 and-3), it is …
independent immunoglobulin-like protein. Along with other Nectins (Nectin-1,-2 and-3), it is …
Resveratrol nanoparticle attenuates metastasis and angiogenesis by deregulating inflammatory cytokines through inhibition of CAFs in oral cancer by CXCL-12/IL-6 …
Cancer-associated fibroblasts (CAFs) are one of the highly abundant components in the
tumor microenvironment (TME). They secrete several cytokines, which amplified tumor …
tumor microenvironment (TME). They secrete several cytokines, which amplified tumor …
Quinacrine inhibits HIF-1α/VEGF-A mediated angiogenesis by disrupting the interaction between cMET and ABCG2 in patient-derived breast cancer stem cells
Background Breast cancer stem cells (BCSCs) have a critical role in progression of breast
cancer by inducing angiogenesis. Several therapeutic strategies have been designed for the …
cancer by inducing angiogenesis. Several therapeutic strategies have been designed for the …
The anti-nectin 4: a promising tumor cells target. A systematic review
W Bouleftour, A Guillot, N Magne - Molecular cancer therapeutics, 2022 - AACR
The Nectin cell adhesion protein 4 (Nectin-4) is overexpressed in multiple human
malignancies. Such aberrant expression is correlated with cancer progression and poor …
malignancies. Such aberrant expression is correlated with cancer progression and poor …
[HTML][HTML] Enfortumab vedotin in metastatic urothelial carcinoma: survival and safety in a European multicenter real-world patient cohort
S Zschäbitz, N Biernath, T Hilser, A Höllein… - European Urology Open …, 2023 - Elsevier
Background Treatment options for patients with urothelial cancer (UC) refractory to platinum
and immunotherapy are limited and survival is short. Enfortumab vedotin (EV) is a …
and immunotherapy are limited and survival is short. Enfortumab vedotin (EV) is a …
Near-infrared enhances antiangiogenic potentiality of quinacrine-gold hybrid nanoparticles in breast cancer stem cells via deregulation of HSP-70/TGF-β
Aim: This study aimed to explore the antiangiogenic mechanism of quinacrine-gold hybrid
nanoparticle (QAuNP) and near-infrared (NIR) radiation in patient-derived primary breast …
nanoparticle (QAuNP) and near-infrared (NIR) radiation in patient-derived primary breast …
Molecular and structural basis of TIGIT: Nectin-4 interaction, a recently discovered pathway crucial for cancer immunotherapy
TIGIT (T cell immunoglobulin and ITIM domain) is an inhibitory receptor expressed on T and
NK cells that interact with cell surface glycoprotein belonging to the nectin and nectin-like …
NK cells that interact with cell surface glycoprotein belonging to the nectin and nectin-like …
[HTML][HTML] Therapeutic prospects of nectin-4 in cancer: applications and value
K Li, Y Zhou, M Zang, X Jin, X Li - Frontiers in Oncology, 2024 - frontiersin.org
Nectin-4 is a Ca 2+-independent immunoglobulin-like protein that exhibits significantly
elevated expression in malignant tumors while maintaining extremely low levels in healthy …
elevated expression in malignant tumors while maintaining extremely low levels in healthy …
Clinical significance of nectins in HCC and other solid malignant tumors: implications for prognosis and new treatment opportunities—a systematic review
J Klekowski, D Zielińska, A Hofman, N Zajdel… - Cancers, 2023 - mdpi.com
Simple Summary Nectins are attracting increased interest as potential markers for
prognosis. In this review, we summarize the results of studies concerning the prognostic …
prognosis. In this review, we summarize the results of studies concerning the prognostic …