Nearly 100 proteins are known to be regulated by hsp90. Most of these substrates or “client
proteins” are involved in signal transduction, and they are brought into complex with hsp90 …

Heat-shock protein 90 (Hsp90) is an abundant and highly conserved molecular chaperone
that is essential for viability in eukaryotes. Hsp90 fulfills a housekeeping function in …

We used a cellular system to elucidate the molecular determinants of the large immunophilin
FK506-binding proteins (FKBP) 51 and-52 for their action on the glucocorticoid receptor in …

The glucocorticoid receptor is a known regulator of a variety of physiological processes. Its
mode of action is well defined: upon hormone binding, it undergoes a conformational …

We have identified a new first step in the hormonal activation of the glucocorticoid receptor
(GR). Rather than causing immediate dissociation of the cytoplasmic GR heterocomplex …

Calmodulin CaM is a ubiquitous Ca2+ sensor protein (16 to 18 kD) with no catalytic activity
that can, upon binding Ca2+, activate target proteins involved in various cellular processes …

FKBP51 and FKBP52 are diverse regulators of steroid hormone receptor signaling,
including receptor maturation, hormone binding and nuclear translocation. Although …

The glucocorticoid receptor (GR) belongs to the superfamily of steroid receptors and is an
important regulator of physiological and metabolic processes. In its inactive state, GR is …

Squirrel monkeys have high circulating cortisol to compensate for expression of low-affinity
glucocorticoid receptors (GRs). We have demonstrated that the FK506-binding …

Steroid hormone receptors (SHRs) are notorious intracellular travellers, transiting among
different cellular compartments as they mature, are subjected to regulation and exert their …